PSMC2

PSMC2

A gene on chromosome 7q22.1-q22.3 that encodes a 26S protease subunit involved in the ATP-dependent degradation of ubiquitinated proteins. It interacts with NDC80, PAAF1, SQSTM1 and HIV-1’s Tat, modulating Tat-mediated transactivation.
References in periodicals archive ?
When the researchers ranked the 56 CYCLOPS genes by the degree to which the cancer cells were dependent on them, the gene that topped the list was PSMC2.
Mapping of the CCK, PSMC2, PSMC4, PSMD1, CPB1and PSPH genes in cattle.
Proteasomal components appear to be equally susceptible to age-dependent decline, with documentation of a downregulation of transcripts encoding for 20S proteasome subunits (Psma6, Psmb1, Psmb2, Psmb4, and Psmb5), ATPase (Psmc2, Psmc3, and Psmc5), as well as the non-ATPase subunits of the 19S regulator (Psmd4, Psmd8, Psmd9, and Psmd12) [3, 97] (Table 1).