DLG4

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DLG4

A gene on chromosome 17p13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family that forms a complex with another MAGUK, DLG2, and is recruited into NMDA receptor and potassium channel clusters. DLG2 and DLG4 may interact at postsynaptic sites to form a multimeric scaffold for clustering of receptors, ion channels and signalling proteins.
References in periodicals archive ?
PSD95 (Postsynaptic density protein 95) is the most important scaffold protein on the postsynaptic membrane, which plays an important role in the process of synapse formation.
A significant increase in C1q and PSD95 colocalization was also observed in J20 mice and also in wild-type (WT) mice when injected with A[beta] oligomers.
(20) PSD95 comprises three PDZ domains, one GK domain, and one SH3 domain.
In contrast, exposure to A[beta]42 downregulated total Akt (Figures 5(a) and 5(c)), p-Akt (Figures 5(a) and 5(d)), and PSD95 (Figures 5(a) and 5(f)), whereas Cur and/or SLCP treatments restored their levels (p < 0.05).
Antibodies detecting HSP70 (4873S, dil 1: 1000) and PSD95 (ab18258, dil 1: 1000) were purchased from Cell Signaling Technology (Danvers, USA) and Abcam (Cambridge, USA), respectively.
A previous study [70] showed that microglia contribute to synaptic pruning during development, and PSD95 (postsynaptic component) or SNAP25 (presynaptic component) was coexpressed in microglia in the hippocampus, indicating that microglia engulf synaptic components.
PSD95 is the postsynaptic membrane marker and SYP is the presynaptic membrane marker [36].
Snyder, "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95," Neuron, vol.
During maturation, as SAP102 is replaced by PSD95, NMDARs with GluN2A replace NMDARs with G1uN2B (Sans el al., 2000; Elias et al., 2008).
Primero, el extremo carboxilo terminal de NOS1AP se une con el dominio PDZ de la oxido nitrico sintasa neuronal (nNOS), que a su vez interactua con la proteina PSD95. La PSD95 une los receptores de glutamato N-Metil-D-Aspartato (NMDA) a la nNOS, lo que lleva a la produccion de oxido nitrico (NO).
The new study shows how the drug, called a "PSD95 inhibitor" prevents brain cell death and preserves brain function when administered after a stroke has occurred.