BRCA1

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Related to PSCP: Public Service Commission

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Huawei made the lowest bid of Rs 16 billion for PSCP, however, this amount was brought down to Rs 12 billion thus saving of Rs 4 billion of public money, he added.
Since the role of the PSCP has not yet been claimed by any one provider group, there could be other professions interested in performing such a role.
The typical morphologic features of PSCP are papillary architecture and slitlike spaces between branching papillae.
The PSCP Steering Committee has heard from a number of speakers on just how dangerous the cyber threat has become in a short period of time.
Waco City Councilmember Wilbert Austin hosted the committee, which is led by PSCP Chair Erich Hackney, councilmember, Lumberton, N.C., Vice Chair Pete Constant, councilmember, San Jose, Calif., and Vice Chair Ike Robinson, councilmember, West Palm Beach, Fla.
The Public Safety and Crime Prevention Committee (PSCP) examined several issues related to community safety during the course of the year.
(For more on the PSCP meeting, see story on page 4.)
Last week, NLC's Public Safety and Crime Prevention (PSCP) Steering Committee held its fall meeting in San Jose, Calif.
NLC's Public Safety and Crime Prevention (PSCP) Steering Committee held its spring meeting in SeaTac, Wash., last month.
The seven committees include: Community and Economic Development (CED); Energy Environment and Natural Resources (EENR); Finance, Administration and Intergovernmental Relations (FAIR); Human Development (HD); Information Technology and Communications (ITC); Public Safety and Crime Prevention (PSCP); and Transportation and Infrastructure and Services (TIS).
Gil Kerlikowske spoke with NLC's Public Safety and Crime Prevention (PSCP) Steering Committee at its fall meeting in Thornton, Colo., last month, as the committee focused on substance abuse issues.