(PSAV) and acceleration (PSAA) can be easily derived.
In order to improve specificity and sensitivity of PSA test for early detection of PCa, some strategies, such as measuring PSA velocity
(rate of change in serum PSA level over time), PSA doubling time (PSA dynamics), and PSA density (adjusting the level of PSA to the size of the prostate gland) have been proposed (14).
Postoperative PSA and PSA velocity
identify presence of prostate cancer after various surgical interventions for benign prostatic hyperplasia.
PSA-related variables include free PSA, free/T ratio, PSA density, and PSA velocity
. The combination of PSA screening and DRE is currently recognized as the optimal screening method for the detection of early PCa.
(2) Several PSA derivatives, including free PSA (fPSA), percentage of free-to-total PSA ratio (%fPSA), PSA density (PSAD), and PSA velocity
(PSAV) have made a major improvement in patient selection for prostate biopsy.
Hence, there is a need of estimation and interpretation of different PSA forms like free PSA levels, prostatic density, PSA velocity
Differences were also found in the ability of different measures of PSA, such as PSA velocity
, PSA density, and PSA doubling time for predicting progression or reclassification.
(15) PSA density (adjusted for prostate volume determined by ultrasound) can improve test accuracy at intermediate PSA levels, (16) and PSA velocity
, change in PSA level over time, has also been examined to differentiate tumor from benign disease.
"We think that we've seen a leveling of overdetection, but I think we'll see another round of overdetection, because of a lowering PSA threshold to prompt biopsy; aggressive rescreening, the use of PSA velocity
at low PSA values to prompt biopsy, and the use of saturation biopsies," he said during the conference, sponsored by the American Association for Cancer Research and the Prostate Cancer Foundation.
Men in the study had a PSA greater than 4 ng/mL and/or a suspicious digital rectal examination and/or a PSA velocity
(PSAV) of greater than 0.75 ng/mL/year, but with a negative prostate biopsy.
Another PSA derivative of feasible importance is PSA velocity
(PSAV), though the available data are also quite controversial.