2) Several PSA derivatives, including free PSA (fPSA), percentage of free-to-total PSA ratio (%fPSA), PSA density
(PSAD), and PSA velocity (PSAV) have made a major improvement in patient selection for prostate biopsy.
Conclusion: In conclusion, it was found that the most important prognostic factors affecting BR were surgical margin positivity and high tumor density; PSA density
, PNB tumor percentage and number of focus were alone associated with high tumor density among the preoperative predictive factors and all predictive factors were positively correlated with tumor density.
The diagnostic accuracy of digital rectal examination, transrectal ultrasonography, prostate-specific antigen (PSA) and PSA density
in prostate carcinoma.
PIRADS version 1 scores (T2, DWI, and overall), lesion size, prostate-specific antigen (PSA), PSA density
, and prostate gland volume were compared between positive and negative biopsy groups and between clinically significant cancer and remaining cases.
VERY LOW-RISK CANCER: Stage T1c; Gleason score of six or lower; PSA level less than 10 ng/ml; fewer than three positive prostate biopsy cores, with cancer In only half or less of each core; PSA density
less than 0.
7% of which 84% were categorized as significant, where the predominant variable for categorization was the PSA density
greater than 0.
In this study, we proposed a novel PSA-related parameter named PSA density
variation rate (PSADVR) and designed a clinical trial to evaluate its potential diagnostic value for detecting PCa on a second prostate biopsy.
(PSAD) measures the amount of PSA relative to the overall prostate size in cubic centimeters as determined by ultrasound or MRI.
These parameters included increasing age, PSA density
, and the number of positive cores.
Some investigators advocate prostate biopsy only if the PSA density
15) PSA density
(adjusted for prostate volume determined by ultrasound) can improve test accuracy at intermediate PSA levels, (16) and PSA velocity, change in PSA level over time, has also been examined to differentiate tumor from benign disease.
IQR: interquartile range; PSA: prostate-specific antigen; PSAD: PSA density
(value PSA prior to surgery divided by volume prostate cancer in prostatectomy specimen); RP: radical prostatectomy; Nx, not taken; NA: not applicable.