It can be used to measure the size of the prostate gland, which can help determine the PSA density
(described in Prostate Cancer Prevention and Early Detection) and may also affect which treatment options a man has.
In order to improve specificity and sensitivity of PSA test for early detection of PCa, some strategies, such as measuring PSA velocity (rate of change in serum PSA level over time), PSA doubling time (PSA dynamics), and PSA density
(adjusting the level of PSA to the size of the prostate gland) have been proposed (14).
They found that men with intermediate-risk cancers in grade group 1 (Gleason score 6), PSA levels of 10 to 15 nanograms per milliliter (ng/ml), and PSA density
below 0.15 were no more likely than those with low-risk disease (grade group 1, PSA less than 10 ng/ml) to have their cancer reclassified to a more aggressive form at the time of surgery.
Serum markers include prostate specific-antigen (PSA) kinetics during AS as PSA doubling time, PSA uelocity, PSA density
or the percent free PSA.
The PSA and PSA density
were both higher in the diagnosis cohort.
The lowest was in group 4, operated in 2015, with p < 0.0001, compared with the surgeries performed in 2012, 2013, and 2014, even with worse PSA density
in the cases of surgery in 2014 compared to the cases operated in 2012 and 2013 (p = 0.01 and 0.03, respectively).
Adjusting the multivariate Cox regression analysis for the presurgical variables age, preoperative PSA, PSA density
, biopsy Gleason grade group, percent tumor positive biopsy cores, clinical stage, or the prognostic CAPRA score  resulted in a significant independent contribution to the prediction of postsurgical BCR for the continuous PDE4D7 score (Tables 2(a), 2(b)).
Patients who met Epstein's criteria for very low risk disease (clinical stage T1c, PSA density
<0.15 ng/ml, biopsy Gleason score <6, presence of PCa in fewer than 3 biopsy cores and no more than 50% involvement in any of the cores) were included for analysis .
(2) Several PSA derivatives, including free PSA (fPSA), percentage of free-to-total PSA ratio (%fPSA), PSA density
(PSAD), and PSA velocity (PSAV) have made a major improvement in patient selection for prostate biopsy.
Conclusion: In conclusion, it was found that the most important prognostic factors affecting BR were surgical margin positivity and high tumor density; PSA density
, PNB tumor percentage and number of focus were alone associated with high tumor density among the preoperative predictive factors and all predictive factors were positively correlated with tumor density.
The diagnostic accuracy of digital rectal examination, transrectal ultrasonography, prostate-specific antigen (PSA) and PSA density
in prostate carcinoma.
PIRADS version 1 scores (T2, DWI, and overall), lesion size, prostate-specific antigen (PSA), PSA density
, and prostate gland volume were compared between positive and negative biopsy groups and between clinically significant cancer and remaining cases.