PSA


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PSA

Abbreviation for prostate-specific antigen.

PSA

prostate-specific antigen.

PSA

abbr.
1. prostate-specific antigen
2. public service announcement

PSA

1 abbreviation for pressure-sensitive adhesive.
2 abbreviation for prostate-specific antigen.

PSA

Prostate-specific antigen. A 34-kD glycoprotein serine protease (formally, kallikrein-related peptidase 3) encoded by KLK3 on chromosome 19q13.41, which has significant homology with other neutral proteases. It is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is increased in patients with both benign (acute inflammation and BPH) and malignant (cancer) prostate lesions;. Most serum PSA is bound to protease inhibitors, including alpha1-antichymotrypin (the form usually measured in the lab), alpha1-macroglobulin, and in far lower amounts to alpha1-antitrypsin; small amounts of PSA in the circulation are not bound—i.e., free—to a carrier protein. Prostate cancer is present in 22% of those with PSA levels above 4.0 µg/L, and 60% of those with levels above 10 µg/L.

PSA

Prostate-specific antigen Urology A 34 kD glycoprotein serine protease with significant homology with other neutral proteases; PSA is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is ↑ in Pts with both benign–acute inflammation and BPH and malignant–CA prostate lesions; most serum PSA is bound to protease inhibitors, including α1-antichymotrypin–the form usually measured in the lab, α1-macroglobulin, and in far lower amounts to α1-antitrypsin; small amounts of PSA in the circulation are not bound–ie, free—to a carrier protein; prostate CA is present in 22% of those with PSA levels above 4.0 µg/L, 60% of those with levels above 10 µg/L

PSA

Abbreviation for prostate-specific antigen.

PSA

See PROSTATE-SPECIFIC ANTIGEN.

PSA (Prostate specific antigen)

A tumor marker associated with prostate cancer.
Mentioned in: Tumor Markers

Patient discussion about PSA

Q. Would kidney stones affect a PSA reading? Would drinking lots of grapefruit juice affect a PSA reading? My husband's PSA reading jumped from a 4.2 to a 17 in @ 2 years' time. How can that be? This man takes all sorts of supplements and really watches his diet. He also takes good care of his body, and does NOT look or act 68.

A. You should get your parathyroid gland checked out. Your calcium level might be causing the kidney stones.

Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.

A. High values don't always mean it's cancer. At 67 years old, you're prostate is most likely enlarging, resulting in the higher PSA results. And after two negative biopsies, it sounds like you're in the clear. Like Brandon said though, keep up with your regular check ups.
Source: http://www.northshore.org/healthresources/encyclopedia/encyclopedia.aspx?Version=Q3_08&DocumentHwid=hw5522&ViewHwid=hw5548

More discussions about PSA
References in periodicals archive ?
PSA Density (3)--It is the PSA produced per gram of prostate tissue.
Recently, an isoform of free PSA has gained attention because of its increased specificity for prostate cancer, supplementing information from initial PSA test results.
Efforts are being made to standardise PSA assays so as to improve harmonisation of results for patient serum samples.
4); addition of a 100- to 1000-fold molar excess of native ACT, and lower storage temperatures were found to help prevent the dissociation of PSA from the PSA-ACT complex (6).
Tum hastalarin operasyon oncesi parmakla rektal muayenesi (PRM), serumda total ve serbest PSA duzeyleri, transrektal ultrasonografisi (TRUS), uroflovmetri ve uluslararasi prostat semptom skorlamasi (IPSS) yapildi.
PSA measurements that prompted reflexive free PSA measurements were classified according to the following indications:
The PSA velocity is also a highly significant independent predictor in the subgroup of men with total PSA levels less than 4 ng/mL.
Generally, no single property is enough to determine the PSA screenability.
After one year, the men on the vegan diet (who were getting 10 percent of their calories from fat) had a small but statistically significant drop in PSA levels, while the control group had a rise in PSA, Ornish reported at a recent scientific meeting.
One study included 316 men who had serum total PSA levels of 2.