PSEN2

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PSEN2

A gene on chromosome 1q31-q42 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, or in linking chromatin to the nuclear membrane; it may also play a role in sorting proteins in the cytoplasm.

Molecular pathology
Defects in PSEN2 are a cause of Alzheimer disease type 4 and cardiomyopathy dilated type 1V.
References in periodicals archive ?
PPP's Dr Sohrab Sarki won PS-2 (Thull) by securing 30,338 votes.
The unit is larger than Sony's PS-2 or Nintendo's GameCube.
The Xbox controller has more buttons and a lot more weight - about 45 per cent more than the GameCube controller and nearly double the weight ofthe PS-2 controller.
The Xbox power switch is on the front of the unit, a big improvement over the PS-2, where the button is inconveniently located at the back.
Unlike GameCube, Xbox and the PS-2 are made to play DVD movies.
Xbox has 64 megabytes of total memory, double the PS-2 for instance, and the speed of its processing units are also dramatically faster.
As a result, Xbox's graphics, at least to a layperson, may not look dramatically better than GameCube or even the PS-2.
Another 20 candidates filed their papers for PS-2 Thull and 15 for PS-3 Garhi Khero.
For PS-2 Thull, the form of Mir Tahir Khoso of PTI was accepted.