PRNP

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PRNP

A gene on chromosome 20p13 that encodes a membrane glycosyl-phosphatidylinositol-anchored glycoprotein, which aggregates into rod-like structures and contains a highly unstable region of five tandem octapeptide repeats. The exact function of PrP is unknown.

Molecular pathology
PRNP mutations are linked to Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington-like disease 1 and kuru.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Using this model, the research team found for the first time that PrPC is over-produced in schwannoma compared with healthy Schwann cells.
The PRPC worked with other jurisdictions that shared the need for mass notification, creating the Alliance for Community Solutions, a group of stakeholders with a common interest in developing and implementing cost-effective, technology-based emergency management tools that benefit the group.
Next, the design procedures of schemes with RSPC and per relay power constraint (PRPC) are described respectively in section III and IV.
Prions sao particulas proteicas infecciosas compostas, quase que exclusivamente, por uma proteina conhecida como prion scrapie (PrPc).
Another innovative example is Massachusetts' Medicaid Primary Care Payment Reform (PRPC), which uses a PMPM and shared risk/savings model to care for the medical and behavioral health needs of this vulnerable population within the PCMH (see www.nashp.org for an overview of Massachusetts' Primary Care Payment Reform Initiative).
As a membrane protein, PrPC follows the secretory pathway to its destination on the outer leaflet of the plasma membrane where it ultimately follows the endocytic pathway for degradation in lysosomes.
Petronas entered the 30-year JV agreement through its unit Petronas Refinery and Petrochemical Corporation (PRPC).
"Our plans are not based on shoppers prpC getting any richer." But he remained confident about the festive period, launching a heart wrenching Christmas advert last night.
In mammals only one disease-causing prion protein is known and is referred to as PrPC in its correct, non pathogenic form and PrPSc in the pathological prion form.
Recently, it was demonstrated by a combination of in vivo and in vitro studies that A[beta] binding to the cellular prion protein (PrPc), an oligomer-specific high-affinity binding site for A[beta], can play a central role in A[beta]-induced memory deficits, axon degeneration, synapse loss, and neuronal death in the AD brain through Fyn kinase activation [40].