PRP40 pre-mRNA processing factor 40 homolog A | definition of PRP40 pre-mRNA processing factor 40 homolog A by Medical dictionary
PRPF40A (redirected from PRP40 pre-mRNA processing factor 40 homolog A)
PRPF40A A gene on chromosome 2q23.3 that encodes a PRPF40 family protein which binds to WASL, suppressing its translocation from the nucleus to the cytoplasm and inhibiting its activity. PRPF40A plays a role in regulating cell morphology, cytoskeletal organisation and cell migration, and may play a role in cytokinesis and pre-mRNA splicing. It is widely expressed, especially in the cerebral cortex.
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References in periodicals archive
CSTF1: cleavage stimulation factor, 31 pre-RNA, subunit 1,50 kDa; CSTF3: cleavage stimulation factor, 31 pre-RNA, subunit 3,77 kDa; DDX1: DEAD (Asp-Glu-Ala-Asp) box helicase 1; FUS: fused in sarcoma; HNRNPAB: heterogeneous nuclear ribonucleoprotein A/B; HNRNPC: heterogeneous nuclear ribonucleoprotein C (C1/C2); HNRNPK: heterogeneous nuclear ribonucleoprotein K; NONO: non-POU domain containing, octamer-binding; PTBP1: polypyrimidine tract binding protein 1; PRPF40A: PRP40 pre-mRNA processing factor 40 homolog A