PROKR2

PROKR2

A gene on chromosome 20p12.3 that encodes the G protein-coupled receptor for prokineticin 2, one of a family of proteins that promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. PROKR2 activation mobilises calcium, stimulates phosphoinositide turnover and activates p44/p42 mitogen-activated protein kinase.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Also, they have demonstrated low or absent levels of expression for EG-VEGF receptors (PROKR1 and PROKR2) in ectopic endometriotic tissues.
EG-VEGF (also known as prokineticin-1) and prokineticin-2 act on 2 receptors, namely, PROKR1 and PROKR2 [14,25,26].
(2) Apart from KAL1 (Xp 22.3), the genes responsible for the KS phenotype are the KAL2 [fibroblast growth factor receptor 1] (FGFR1) gene (10%) and the KAL4 [Prokinetecin receptor 2] (PROKR2) and KAL3 [Prokinetecin 2] (PROK2) (9%) genes.
(2.) Hardelin JP, Dode C, 2008 The complex genetics of Kallmann syndrome: K AL1, FGFR1, FGF8, PROKR2, PROK2, et al.
Lee et al., "Chlamydia trachomatis infection increase fallopian tube PROKR2 via TLR2 and NF-[kappa]B activation resulting in a microenvironment predisposed to ectopic pregnancy," The American Journal of Pathology, vol.
Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations.
Increased production of this protein - known as PROKR2 - makes a pregnancy more likely to implant in the Fallopian tube.
Mutations in the prokineticin 2 peptide (PROK2) and its transmembrane domain type 2 receptor (PROKR2) are newly identified molecular culprits in autosomal KS.
The PROK2 gene encodes prokinetecin 2, an 81 amino acid peptide that signals via the G protein-coupled product of the PROKR2 gene.
Recently, a digenic combination of monoallelic variants in PROKR2 and WDR11 has been reported to be responsible for a pituitary stalk interruption syndrome in a child (46).
Following this guideline, Bergman and colleagues [51] performed the CHD7 analysis in a cohort of 36 Dutch KS patients (previously excluded to carry mutations in FGFR1, PROK2, PROKR2, and FGF8), identifying 3 heterozygous CHD7 mutations in patients having same features of CHARGE syndrome.
To date, at least 17 genes have been associated with KS and these include KAL1, FGFR1, PROK2, PROKR2, FGF8, HS6ST1, CHD7, WDR11, SEMA3A, FGF17, IL17RD, DUSP6, SPRY4, FLRT3, NELF, FEZF1, and CCDC141 (3).