PROKR1

PROKR1

A gene on chromosome 2p13.1 that encodes the G protein-coupled receptor for prokineticin 1, one of a family of secreted proteins that promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. PROKR1 is exclusively coupled to the G(q) subclass of heteromeric G proteins; its activation mobilises calcium, stimulates phosphoinositide turnover and activates p44/p42 mitogen-activated protein kinase.
References in periodicals archive ?
PROKR1 can allow the egg to implant correctly inside the womb, but when it's in the fallopian tubes, it's believed to increase the risk of this occurring outside the womb.
Women who smoked and developed an ectopic pregnancy had two times more PROKR1 in their fallopian tubes as women who did not smoke, and had an earlier healthy pregnancy.
Researchers found that female smokers who have had an ectopic pregnancy have raised levels of a harmful protein - PROKR1 - in their fallopian tubes, caused by a chemical in smoke.
The protein, called PROKR1, raised the risk of an egg implanting outside the womb.
PROKR1 allows pregnancies to implant correctly inside the womb, but its presence in the Fallopian tubes is believed to increase the risks of this happening outside the womb.