PRKCQ

PRKCQ

A gene on chromosome 10p15 that encodes a member of the protein kinase C family, which is a calcium-independent and phospholipid-dependent, serine- and threonine-specific protein kinase, that plays a key role in T-cell activation and is required for activating transcription factors NF-kappaB and AP-1, and which may link the T-cell receptor.
References in periodicals archive ?
DAISY children were genotyped for fourteen non-HLA T1D candidate SNPs: C1QTNF6 (rs229541), C6orf173 (rs9388489), C14orf181 (rs1465788), IL2 (rs2069762), IL2 (rs4505848), IL2RA (rs12722563), IL2RA (rs2104286), IL7R (rs6897932), PRKCQ (rs947474), SKAP2 (rs7804356), SMARCE1 (rs7221109), TLR8 (rs5979785), UBASH3A (rs3788013), and SNP (rs10517086).
In the analyses examining development of IA, all of the SNPs were treated additively, except IL2RA (rs12722563) and PRKCQ (rs947474), which were dichotomized on the minor allele due to small sample sizes.
Peripheral T-cell lymphoma NOS has higher expression of PRKCQ (protein kinase C 0), which regulates survival after T-cell activation) and FYN and decreased expression of FAS and Caspase 10, which would lead to proliferation and loss of apoptosis and a more aggressive disease course.