PRKCA


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PRKCA

A gene on chromosome 17q22-q23.2 that encodes a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, which up- or downregulates cell proliferation, apoptosis, differentiation, migration and adhesion; tumourigenesis; cardiac hypertrophy; angiogenesis; and platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signalling cascades involving MAPK1/3 and RAP1GA.
References in periodicals archive ?
PRKCA (Protein Kinase C Alpha), also a target gene of hsa-miR-3148, was enriched in 15 of 16 KEGG pathways, such as pathways in cancer, glioma, and ErbB signaling pathway.
PRKCA, also a target gene of hsa-miR-3148, was enriched in pathways in cancer, glioma, and ErbB signaling pathway.
For the two significant SNPs on SSCs 12 and 16 associated with CWT, we found two candidate genes namely protein kinase C, Alpha (PRKCA) and survival of motor neuron (SMN).
identified many AD-related genes coregulating with App including Gsk3b, Falz, Mef2a, Tlk2, Rtn, and Prkca [6].
Multiple protein kinase transcripts were affected by PB and/or PTU exposure, including the up-regulation of Prkcz (PB and PTU) and PKC[alpha] (Prkca), and down-regulation of protein kinase A [Prkaa; GenBank accession no.