PRKAR2BA gene on chromosome 7q22 that encodes one of the regulatory subunits of cAMP-dependent protein kinase, which transduces activating signals by phosphorylating different target proteins. PRKAR2B interacts with cAMP-responsive element-binding protein 1 (CREB1) in activated T cells and suppresses transcription. Knockout studies in mice suggest that PRKAR2B may play a role in regulating energy balance and adiposity.
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