major basic protein

(redirected from PRG2)

major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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For men, DNAJB5, RAC3, EAPP, HDLBP, PRG2, PER1, PIK31, and SLA2 were selected for validation, whereas for women the gene list for validation included AKAP6, LIMK1, SIRT7, ARHPGAP4, ATG16L2, TPM3, 5-HT1B, and PYGO2.
(4) performance of gene set consisting of DNAJB5, RAC3, SLA2, HDLBP, PRG2, PER1, PIK3R1, and EAPP to dinstinguish between high and low [PM.sub.10] exposure in men (above 75th percentile corresponding to 24.5 [micro]g/[m.sup.3]) and low (< 24.5 [micro]g/[m.sup.3]) and (B) performance of gene set consisting of ARHGAP4, AKAP6, PYGO2, HTR1B, ATG16L2, SIRT7, TPM3 and LIMK1 in women to distinguish between high (above 75th percentile corresponding to: 25.7 Mg/m3) and low (< 25.7 Mg/m3) long-term residential [PM.sub.10] exposure.
"An employee with a diploma working in a university hospital earns 3 million RLS per month, while his counterpart in a social security hospital earns 6 million RLS" (PRG2).
One may start the day happily, but this physical environment causes it to end it up sad" (PRG2).
I sleep every night with stress" (PRG2); "We had a patient with hepatitis.
Gene ontology: biological Genes p-Value process terms Cell cycle CCNB1, CCNB2, MNAT1, CDC2, 2.7 E-14 CDKN 1 A, CDKN3, CDKN2A, ANAPC1, CDK10 Cellular metabolism KRT15, KIF1B, ZNF697, 4.3E-13 PRG2, P2RY2,IMMP2L Growth factor and growth BMP-2, TCF[beta]1, VEGF, 1.2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6, FTH1, DHCR7 2.1E-8 Signal transduction MAP2K3, MAPK14, MAP3K10, BAMBI, NDRG2, ECM1, SMAD7 5.5E-7 Apoptosis MYC, P53AIP1, ZBTB16, BBC3, 1.3E-5 VHL, CASP3, APITD1 Table 5 KEGG pathway analysis.