Stout et al., "Detection of Huntington's disease decades before diagnosis: the Predict-HD
study," Journal of Neurology, Neurosurgery & Psychiatry, vol.
Longitudinal research in the PREDICT-HD  and other clinical programs  indicates that HD patients develop subtle changes decades before classical presentation.
Johnson et al., "Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study," Frontiers in Aging Neuroscience, vol.
Stout, and Predict-HD
Investigators of the Huntington Study Group, "Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD
study," Biological Psychiatry, vol.
[sup], Large studies of gene-positive individuals, most notably PREDICT-HD and TRACK-HD, have provided abundant evidences that changes of brain imaging and cognitive testing were detectable years before the expected clinical diagnosis.
Langbehn DR, Hayden MR, Paulsen JS, PREDICT-HD Investigators of the Huntington Study Group.
Langbehn et al., "Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD
study," Movement Disorders, vol.