PRDM1

PRDM1

A gene on chromosome 6q21 that encodes a protein which represses beta-interferon gene expression, by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. PRDM1 transcription increases in response to viral induction.
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Alarge-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
MiR-30a decreases cell proliferation by targeting PRDM1 served as downstream of a sequential RAWnt-Fgf signaling cascade, inhibiting the [beta]-catenin expression in both the cytoplasm and nucleus [34].
[157] created tumor suppressor gene PRDM1 -modified NK cells as models of natural killer cell lymphoma and have shown that gene editing of NK cells can be a powerful approach to study functional alterations in human tumor suppressor genes.
H3K9 is methylated by the KMT1 family (SUV39H1, SUV39H2, G9A, GLP, SETDB1, and SETDB2) as well as PRDM1, PRDM2, and PRDM4.
Based on motif analysis of PAX5, we searched out 28 PAX5 target genes, that is, BAX, BCL2, BLK, CCND1, CD19, D79A, CDKN1A, FCER2, FHL2, LEF1, MET, MMP1, MYCNA, PRDM1, PRKCE, RAG2, RB1, TIMP1, TP53, XBP1, EGR1, ESR1, ELK1, ETS1, KCNH4, VPREB1, IGLL1, and KCNH8.
Results indicated methylation of RASSF1A, PRDM1, and 3OST2 were useful for early detection at stage 1.
Blimp1 (B-lymphocyteinduced maturation protein1) tambien conocido como Prdm1, funciona mediante la formacion de un complejo con Prmt5 (arginine metiltransferase).
A large scale replication study confirmed some of these associations and identified TNIP1 PRDM1 JAZF1 UHRF1BP1 and IL10 as risk loci for SLE (Gateva et al 2009).
Hom et al., "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as riskloci for systemic lupus erythematosus," Nature Genetics, vol.
Cells with the protective version of both markers expressed PRDM1 after being exposed to radiation.
The researchers further traced this observation to a gene called Prdm1 encoding the protein BLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2).
Analyses at the protein level using flow cytometry further confirmed that IL-23 induces the expression of Bcl6 rather than of Blimp-1 (encoded by PRDM1) on [T.sub.FH] cells [21].