CCND1

(redirected from PRAD1)

CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.
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References in periodicals archive ?
Almost all MCLs, including rare [CD5.sup.-] ones, are positive for cyclin D1, also known as BCL1, CCND1, or PRAD1. (8, 9) Cyclin D1 is a member of the cyclin D protein family.
Cyclin D1 (Bcl1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.
Upregulated genes Downregulated genes (1) Nuclear factor (Nf-116) (1) Epidermal keratin types 1, 13, 15, and 16 (2) Epidermal keratin type II (2) Transforming growth factor beta 3 receptor (3) MEF2C transcription factor (3) Differentiation dependent A4 protein (4) Metalloproteinase (4) Ribosomal proteins L3, L8, L28, L31, and L35 (5) Tyrosine phosphatases CIP 2 (5) ARF activated phosphatidylcholine-specific phospholipase D1a (6) Transforming growth factor (6) Zinc finger protein beta binding protein (7) Mitogen inducible gene 2 (7) DNA binding protein FKHL 15 (8) Oncofetal antigen 5T4 (8) PRAD1
Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation.
PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma.
Detection of cyclin D1(bcl-1, PRAD1) overexpression by a simple competitive reverse transcription-polymerase chain reaction assay in t (11;14)(g13;q32)-bearing B-cell malignancies and/or mantle cell lymphoma.

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