PPT1 | definition of PPT1 by Medical dictionary
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PPT1 A gene on chromosome 1p32 that encodes palmitoyl-protein thioesterase 1, a small glycoprotein enzyme that removes thioester-linked fatty acyl groups such as palmitate from cysteine residues.
PPT1 mutations are linked to neuronal ceroid lipofuscinosis types 1 and 4.
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References in periodicals archive
Researchers further proved that the concept by targeting melanoma cells with DC661, which specifically targets PPT1
and produces cell death in many cell lines tested both in vitro and in vivo.
Enzymatic assays based on fluorescent substrates have recently been reported for PPT1 (2) and TPP1 (3).
For the PPT1 assay, MUTG (3.4 mmol/L) was dissolved in 150 [micro]L chloroform-methanol containing 50 mL/L Triton X-100.
In addition, heating of dried blood cards to 50 [degrees]C for 3 h, which inactivates enzymes in liquid EDTA-blood samples, did not affect TPP1 or PPT1 activities in DBS (data not shown).