SERPINH1

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SERPINH1

A gene on chromosome 11q13.5 that encodes a member of the serpin superfamily of serine proteinase inhibitors that localises to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone.

Molecular pathology
Anti-SERPINH1 autoantibodies occur in patients with rheumatoid arthritis. SERPINH1 expression may be a marker for cancer. Nucleotide polymorphisms may be linked to pre-term labour due to premature rupture of membranes.
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References in periodicals archive ?
It is observed that PPROM was most common between age group 21-30 year.
The incidence of pPROM, preterm delivery, and duration between cerclage and delivery were not significantly different between the two groups; however, the incidence of pPROM appeared higher in the physical examination-indicated group than that in the ultrasound-indicated group (26.7% vs 12.5%).
Moreover, 16 mothers from the PTB group had PPROM, while the rest (n = 49) delivered with intact membranes.
No previous reports have showed that pregnancy with prior myomectomy increases the risk of pPROM. Therefore, we considered that the myomectomy did not affect the onset of pPROM in the present case.
We did not find any statistically significant differences between groups I (n = 57) and Ia (n = 37) and between the groups of patients with preterm uterine contractions (n = 30) and PPROM (n = 27).
Preterm premature rupture of membrane (PPROM) is a common perinatal complication in pregnant women.
Isleme bagli ablasyo plasenta, preterm dogum, PPROM gibi komplikasyonlarin dusuk oranda da olsa gorulebilecegi akilda tutulmalidir.
HIV and chorioamnionitis have mutually deleterious effects on PPROM, as HIV is implicated in the pathogenesis of chorioamnionitis, and HIV-positive patients who develop PPROM are much more likely to develop chorioamnionitis.
However, there is a clear indication that, even when asymptomatic, AV may represent a risk factor for preterm delivery (20,21) and other complications of pregnancy such as ascending chorioamnionitis and PPROM (5,22,23).
Potential obstetric risks of treatment for CIN include infertility, spontaneous abortion, preterm premature rupture of membranes (PPROM), preterm delivery, and perinatal/neonatal mortality.