calcineurin

(redirected from PPP3CA)

cal·ci·neu·rin

(kal'sē-nyūr'in),
A calcium-dependent serine-threonine phosphatase involved in T-cell signaling transcription; the target of cyclosporine immunosuppression; the reaction cascade in which it resides is referred to as the calcineurin pathway.
[calcium + G. neuron, nerve, + -in]

calcineurin

An enzyme which binds Ca2+ and calmodulin, inhibiting calmodulin activity. Calcineurin alters proteins by removing phosphate groups, shortening duration of NMDA channel opening, resulting in synaptic desensitisation of NMDA receptors. Calcineurin activates T cells via transcription factor NFATc (Nuclear Factor of Activated T cell, cytoplasmic) by dephosphorylation. Activated NFATc is translocated into the nucleus, where it upregulates IL-2 expression, and, by extension, the T cell response. Calcineurin is most concentrated in the CNS, and is inhibited by immunophilin ligand, tacrolimus and cyclosporin, both immunosuppressants. Because rejection can be mediated by calcineurin, calcineurin inhibitors (cyclosporine, pimecrolimus and tacrolimus) are used to prevent or manage rejection.

cal·ci·neu·rin

(kal'sē-nūr'in)
A calcium-dependent serine-threonine phosphatase involved in T-cell signaling transcription; the reaction cascade in which it resides is referred to as the calcineurin pathway.
[calcium + G. neuron, nerve, + -in]
References in periodicals archive ?
DNA from the 30 healthy volunteers of the main study was sequenced for the promoter region of PPIA [peptidylprolyl isomerase A (cyclophilin A)], [8] PPP3R1 (protein phosphatase 3, regulatory subunit B, [alpha]), PPP3CA (protein phosphatase 3, catalytic subunit, a isozyme), PPP3CB (protein phospha- 8 tase 3, catalytic subunit, [beta] isozyme), and FKBP1A (FK506 binding protein 1A, 12 kDa) to investigate polymorphisms that could modulate DNA transcription or mRNA stability (see online Supplemental Methods).
PPP3CA rs45441997 (GCC)10/10 is a 5' untranslated region variation located in the promoter region of the catalytic subunit of calcineurin.
8] Human genes: PPIA, peptidylprolyl isomerase A (cyclophilin A); PPP3R1, protein phosphatase 3, regulatory subunit B, a; PPP3CA, protein phosphatase 3, catalytic subunit, a isozyme; PPP3CB, protein phosphatase 3, catalytic subunit, isozyme; FKBP1A, FK506 binding protein 1A, 12 kDa; CALM1, calmodulin 1 (phosphorylase kinase, 8); IL2, interleukin-2; IL2RA, interleukin 2 receptor, a; JUN, jun proto-oncogene; NFATC1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1.
CXCL12, C5 Tachycardia Imipramine GRIN2B, ADORA3, KCNH7, CHRNA7, KCNG2, KCNQ1, CHRNA5, ADORA1, CASQ2, ADRA1B, ADRB3, ADRA1D Kidney failure Imipramine EPO, ALB, EDNRA, FKBP1A, NR3C2, VDR, PPP3CA Glomerular injury EtOH-Fr SREBF1 Cardiac congestive Cardiac failure Imipramine EPO, NOS1.