When there is failure of the normal transition to extra-uterine life, with the persistence of increased PVR, PPHN
This indicates that SSRI exposure "may be" associated with an increased risk of PPHN
, but the magnitude of that risk--if present--is smaller than previous studies have reported, Krista F.
is most often recognized in term or near-term neonates, but it can occur, albeit infrequently, in premature neonates.
Evidence linking SSRIs to an increased risk of adverse birth outcomes often has been based on large, retrospective health system database cohort studies looking at SSRI exposure and associations with conditions such as PPHN
, cardiac anomalies, attention-deficit/hyperactivity disorder, and autism.
The incidence of PPHN
is an estimated ~5% in developed countries.
occurs in 1-2 per 1000 live births in the general population and is associated with substantial neonatal morbidity and mortality.
The authors offer the following conclusions: Antidepressants are not effective for most women with depression; a strong signal for teratogenicity is evident for SSRIs; and outcomes such as preterm birth, PPHN
, and poor neonatal adaptation are common after prenatal exposure to SSRIs.
Solunum yetersizligi nedenleri Solunum yetersizligi nedeni Erken dogan Zamaninda dogan n (%) n (%) SSS 17 (70,8) 0 (0,0) Pnomoni 1 (4,2) 1 (9,1) PPHN
3 (12,5) 1 (9,1) Pnomotoraks 1 (4,2) 1 (9,1) Sepsis 1 (4,2) 1 (9,1) Perinatal asfiksi 1 (4,2) 2 (18,2) Diger 0 (0,0) 5 (45,5) SSS: Sikintili solunum sendromu, PPHN
: Persistan pulmoner hipertansiyon Tablo 3.
They also performed subanalyses on whether other antidepressants with an effect on serotonin activity or norepinephrine activity would affect the risks of PPHN
To see the effects of magnesium in newborn with persistent pulmonary hypertension of newborn (PPHN
) who did not respond to mechanical hyperventilation and are candidates for Extra Corporeal Membrane Oxygenation (ECMO), ten newborns who were admitted to Neonatal Intensive Care Unit (NICU) with profound hypoxia and respiratory failure due to PPHN
were treated with conventional mechanical ventilation and then mechanical hyperventilation.
showed a statistically significant association with late prenatal SSRI exposure (OR 6.
The advisory describes PPHN
as an "uncommon potential risk" that has not been confirmed by other studies, but notes that this finding "adds to concerns" generated from previous reports that infants exposed to SSRIs late in pregnancy may experience irritability, difficulty feeding, and in, "very rare cases," difficulty breathing.