tuberculin

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Related to PPD tuberculin: tuberculin test

tuberculin

 [too-ber´ku-lin]
a sterile liquid containing the growth products of, or specific substances extracted from, the tubercle bacillus; used in various forms in the diagnosis of tuberculosis (see tuberculin test).
Old tuberculin a sterile solution of a heat-concentrated filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
PPD tuberculin (purified protein derivative tuberculin) a sterile solution of a purified protein fraction precipitated from a filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
tuberculin test any of a large number of skin tests for tuberculosis using a variety of different types of tuberculin and methods of application. The most reliable procedure, now standard, is intradermal injection (the mantoux test) of PPD (purified protein derivative); a positive result consists of a palpable and visible area of erythema and induration greater than 10 mm in diameter developing around the site of injection 48 to 72 hours after the injection. Intermediate strength tuberculin (5 TU) is generally used to test adults; a positive result is virtually diagnostic of a previous or current infection with Mycobacterium tuberculosis. Persons with a negative test are retested with second strength tuberculin (250 TU); in this test a positive reaction is frequently due to atypical mycobacteria infection and is thus nonspecific; a negative result indicates either absence of tuberculosis or the presence of cutaneous anergy due to overwhelming tuberculosis infection or to an associated immunocompromised condition such as HIV infection, Hodgkin's disease, or sarcoidosis.

tu·ber·cu·lin

(tū-ber'kyū-lin),
1. A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin
2. One or another of a relatively large number of extracts of Mycobacterium tuberculosis cultures, different from OT and now obsolete.

tuberculin

(to͝o-bûr′kyə-lĭn, tyo͝o-)
n.
A sterile liquid containing proteins extracted from cultures of tubercle bacilli and used in tests for tuberculosis.

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin.

Tuberculin

A mixture of antigens obtained from the cultured bacteria that cause tuberculosis, Mycobacterium tuberculosis.
Mentioned in: Tuberculin Skin Test

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 110 volume at 100°C and filtered.
References in periodicals archive ?
At "Shanyrak" LLP (Bukhar-Zhyrau District), the sensitins' diagnostic effectiveness was tested on 20 cows, whom planned tests with the standard PPD tuberculin solution (manufactured by "Biovet" Scientific and Practical Center" LLP) found to have TB.
Planned annual diagnoses at LLP named after Chapayev (Osakarov district) always found animals, reacting to PPD tuberculin mammalian.
The planned diagnostic examination with PPD tuberculin mammalian of 250 cattle units at LLP named after Asylbekov found 12 (4.8%) units.
avium and PPD tuberculin. All cows had cross-reactions to allergens in different combinations: three (25%) to PPD + M.
avium (3.5+-0.2 mm) and PPD tuberculin mammalian (3.7+-0.1 mm).TB was ruled out after the postmortem examination of two cow carcasses.
Thirteen cattle units that previously reacted to PPD tuberculin were examined at a private farmstead in the Abay district.
The animals were examined in 45 days with the simultaneous administration of PPD tuberculin mammalian (control) and A M sensitins (.avium and .
The remaining four cows that previously reacted to PPD tuberculin mammalian were left at the farmstead under veterinary monitoring.