PPARG

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PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Stimulation of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARgamma) and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts.
Calcium influx induced by TRPV1 activation may cause activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXR[alpha] (McCarty et al., 2015).
Pro12Ala polymorphism in the peroxisome prolif-erator-activated receptor-gamma (PPARgamma) gene in inflammatory bowel disease.
Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes.
PPARgamma and Wnt signaling in adipogenic and osteogenic differentiation of mesenchymal stem cells.
7-ketocholesteryl-9carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARgamma in THP-1 macrophages.
Vidal, "Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects," Journal of Clinical Endocrinology and Metabolism, vol.
Li et al., "Both coactivator LXXLL motif-dependent and-independent interactions are required for peroxisome proliferator-activated receptor gamma (PPARgamma) function," Journal of Biological Chemistry, vol.
Jung, "PPARgamma antagonist gleevec improves insulin sensitivity and promotes the browning of white adipose tissue," Diabetes, vol.
Baba et al., "Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis," Gastroenterology, vol.