PPARG

(redirected from PPARG2)

PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Metabolic imprinting effect in beef production: influence of nutrition manipulation during an early growth stage on PPARg2 and PMRT5 expressions in the longissimus muscle in Wagyu (Japanese Black).
In this context, the polymorphisms PPARG2 Pro12Ala (rs1801282) and IL6 -174G >C (rs1800795) have received attention for their possible influence in body weight regulation [1-3].
Idris et al., "Histone H3 K27 acetylation marks a potent enhancer element on the adipogenic master regulator gene Pparg2," Cell Cycle, vol.
In this regard, the aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism (namely, TCF7L2, PPARG2, PPARGC1A, carbohydrate metabolism; FTO, MC4R, APOA5, LDLR, GCKR, fat metabolism; MTHFR, folate metabolism).
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.
Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
Higgins, "The association between the peroxisome proliferator-activated receptor-[gamma]2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and metaanalysis," American Journal of Epidemiology, vol.
Effect of the Gly972Arg, SNP43 and Pro12Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
The fat-moderating gene is called peroxisome proliferator-activated receptor gamma isoform 2, or Pparg2.
To validation of differentially expressed for differentially methylated genes between groups, we confirmed twelve differentially methylated genes in MeDIP-seq by real-time quantitative PCR, including TGFB3, ACSL1, ryanodine receptor 1 (RYR1), ACOX2, peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), RIN2, microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), ZDHHC13, and SH3 and PX domains 2B (SH3PXD2B).
Han et al., "Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk," BMC Medical Genetics, vol.