PPARA


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PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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The bisulfate-treated genomic DNA was then used as a template for the amplification of promoters of GR PPARa and PPAR.
We found that P-AmPk/AMPK levels exhibited similar change pattern as PPAR[alpha] did (Supplementary Figure 1), suggesting that exercise prevented ketogenic diets induced lipid disorders by decreasing lipid storage via PPAR[gamma], while increasing lipid [beta]-oxidation via PPARa and AMPK.
Wan et al., "Effect of miR-34a in regulating steatosis by targeting PPARa expression in nonalcoholic fatty liver disease," Scientific Reports, vol.
Gene Primers Srebf2 F: 5'-CGCTCCACAGACCAGGATCA-3' R: 5'-TGTCACGAGGCTTTGCACTTG-3' Srebf1 F: 5'-GGAGCCATGGATTGCACATT-3' R: 5'-AGGAAGGCTTCCAGAGAGGA-3' Ppara F: 5'-GACAAGGCCTCAGGATACCACTATG-3' R: 5'-TTGCAGCTTCGATCACACTTGTC-3' Prkaa1 F: 5'-GGCTCGCCCAATTATGCTG-3' R: 5'-AGAGTTGGCACGTGGTCATCA-3' Acaca F: 5'-CAATCCTCGGCACATGGAGA-3' R: 5'-GCTCAGCCAAGCGGATGTAGA-3' [beta]-actin F: 5'-GGAGATTACTGCCCTGGCTCCTA-3' R: 5'-GACTCATCGTACTCCTGCTTGCTG-3' Srebf1: sterol regulatory element binding transcription factor 1; Srebf 2: sterol regulatory element binding transcription factor 2; Ppara: peroxisome proliferator-activated receptor alpha; Acaca: acetyl-coenzyme A carboxylase alpha; Prkaa1: protein kinase, AMP-activated, alpha 1 catalytic subunit.
Svalstedt, "Thiazolidinediones (PPAR[gamma] agonists) but not PPARa agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes," The FASEB Journal, vol.
Experimental studies and animal models have shown that PFAS can act as agonists of the peroxisome proliferator-activated receptor-alpha (PPARa), which might lead to liver damage (Intrasuksri et al.
Zeldin et al., "The epoxygenases CYP2J2 activates the nuclear receptor PPARa in vitro and in vivo," PLoS ONE, vol.
Lee et al., "Liver PPARa and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice," Biochemical and Biophysical Research Communications, vol.
The ability of both CA and FA to prevent HFD-induced hypertriglyceridemia is remarkable and likely to involve i) a direct liver effect to coordinate reduction in the FAS and DGAT-2 expressions during HFD as well as to coordinate the induction of ATGL and PPARa expression and/or ii) an indirect effect mediated via prevention of obesity.
Tenders are invited for supply of poly propylene rope having 4 mm x 3 mm for strand ppara 4 mm yellow colourisi 5175 1992.