PPARA


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PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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Another potential source of SRL pharmacokinetic variability was the rs4253728G>A polymorphism in PPARA.
2]); PECAMI platelet/ endothelial cell adhesion molecule (CD31 antigen); AGTRI, angiotensin II receptor, type 1; AGTR2, angiotensin II receptor, type 2; BDKRBI, bradykinin receptor B1; BDKRB2, bradykinin receptor B2; PPARA, peroxisome proliferator-activated receptor-[alpha]; F7, coagulation factor VII (serum prothrombin conversion accelerator); CETP, cholesteryl ester transfer protein.
058 activated receptor, gamma, coactivator 1, alpha peroxisome proliferative PPARA 2.