peroxisome proliferator-activated receptor-gamma

(redirected from PPAR-gamma)

peroxisome proliferator-activated receptor-gamma

A receptor widely expressed in macrophages, which has been identified as a putative target for novel therapies against inflammatory bowel disease (IBD).

PPAR-gamma deletion significantly exacerbates clinical activity and colonic pathology; impairs the splenic and mesenteric lymph node regulatory T-cell compartment; increases percentages of lamina propria (LP) CD8+ T cells; increases surface expression of CD40, Ly6C and Toll-like receptor 4 (TLR-4) in LP macrophages; and upregulates expression of colonic IFN-γ, CXCL9, CXCL10, IL-22, IL1RL1, CCR1 (suppressor of cytokine-signalling 3), and MHC class-II in mice with IBD.
References in periodicals archive ?
Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Humalog.
The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma.
So the next question was whether sirtuins remove acetyl groups from ppar-gamma and, indeed, that was what we found," said Dr.
The patent is titled "Composition of Labdane diterpenes extracted from Andrographis paniculata, useful for the treatment of autoimmune diseases, and Alzheimer Disease by activation for PPAR-Gamma receptors.
The compound acts as an agonist of PPAR-delta and PPAR-gamma.
The researchers had believed Avandia and Takeda Pharmaceutical Co's Actos work by stimulating a protein known as PPAR-gamma.
Researchers led by scientists from the Pasteur Institute in Lille, France, found that having low levels of a protein called PPAR-gamma, which regulates defenses that kill bacteria in the gut, may make patients less able to fight off gut infections--so boosting PPAR-gamma could help protect against such diseases.
The keynote lecture provides an introduction to the nuclear receptor superfamily and the remaining contributions discuss such topics as metabolic control by LXR receptors, regulation of cardiac energetic by the orphan nuclear receptors ERR-alpha and ERR-gamma, FXR and bile acids as critical modulators of metabolisms, the role of PPARs in human prediabetes, the role of the intestine in reverse cholesterol transport, NR4A nuclear receptors in the vessel wall, cholesterol as a novel target in the treatment of Alzheimer's disease, PPAR-gamma mediated effects in central nervous system disorders, and the role of the orphan nuclear receptor rev-erb-alpha in the molecular biology of circadian rhythms and cardiometabolic disease.
Many of the clinical trials in HIV have included patients who have remained on the tNRTI drugs zidovudine or stavudine, which inhibit PPAR-gamma, so "it is possible that the two drugs cancel each other out with respect to the effect on lipoatrophy," she said.