peroxisome proliferator-activated receptor-gamma

(redirected from PPAR-gamma)

peroxisome proliferator-activated receptor-gamma

A receptor widely expressed in macrophages, which has been identified as a putative target for novel therapies against inflammatory bowel disease (IBD).

PPAR-gamma deletion significantly exacerbates clinical activity and colonic pathology; impairs the splenic and mesenteric lymph node regulatory T-cell compartment; increases percentages of lamina propria (LP) CD8+ T cells; increases surface expression of CD40, Ly6C and Toll-like receptor 4 (TLR-4) in LP macrophages; and upregulates expression of colonic IFN-γ, CXCL9, CXCL10, IL-22, IL1RL1, CCR1 (suppressor of cytokine-signalling 3), and MHC class-II in mice with IBD.
References in periodicals archive ?
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
In addition PPAR-gamma also activated beta-oxidation in macrophages.
Previous studies have shown that a protein called PPAR-gamma controls the development of fat cells and that stress hormones turn on the production of PPAR-gamma.
In the body, PPAR-gamma is a receptor that regulates glucose metabolism.
The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma.
Fluid retention and heart failure with concomitant use of PPAR-gamma agonists: Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin.
Aleglitazar is a peroxisome proliferator--activated receptor (PPAR) co-agonist, activating both PPAR-alpha and PPAR-gamma.
So the next question was whether sirtuins remove acetyl groups from ppar-gamma and, indeed, that was what we found," said Dr.
The patent is titled "Composition of Labdane diterpenes extracted from Andrographis paniculata, useful for the treatment of autoimmune diseases, and Alzheimer Disease by activation for PPAR-Gamma receptors.
The compound acts as an agonist of PPAR-delta and PPAR-gamma.