PPARA

(redirected from PPAR-alpha)

PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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PPAR-alpha L162V and PGC-1 G482S gene polymorphisms, but not PPAR-gamma P12A, are associated with alcohol consumption in a Spanish Mediterranean population.
The American researchers believe that one reason why trials investigating the effects of aspirin on elderly Alzheimer's patients may have seen disappointing results is because the mechanism appears to be dependent on a protein called PPAR-alpha, and levels of this specific protein reduce significantly with age.
mRNA Extraction and Analysis of ApoA5, ApoCIII, PPAR-Alpha, and SREBP1 Genes.
HF-fed mothers cause disrupted PPAR balance in the first generation offspring, favoring the high expression of PPAR-gamma (lipogenic factor) concomitant to decreased expression of PPAR-alpha, essential to mitochondrial beta-oxidation (Magliano et al, 2013).
PPAR-alpha is mainly expressedin liver while PPAR-gamma is predominantly expressed in adipose tissue and the immune system in the adult rat (Braissant et al., 1996) and chickens (Meng et al., 2005).
Specifically, the studies showed an activation of PPAR-alpha, a receptor that promotes the breakdown of fat and lowers cholesterol, and AMPK, an enzyme that promotes energy burn.
Nonogaki et al., "Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice," Endocrinology, vol.
Akin, "PPAR-alpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats," The Turkish Journal of Gastroenterology, vol.
Aleglitazar is a peroxisome proliferator--activated receptor (PPAR) co-agonist, activating both PPAR-alpha and PPAR-gamma.
The cherry diet was also associated with significantly enhanced hepatic PPAR-alpha mRNA, enhanced hepatic PPAR-alpha target acyl-coenzyme A oxidase mRNA and activity, and increased plasma antioxidant capacity.
Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression.
PPAR-alpha antibody was purchased from Abcam (San Francisco, CA).