Expression of AMPK[alpha] promotes fatty acid oxidation by upregulating PPAR gamma
coactivator-lalpha (PGC-1a) gene expression (Wan et al.
is required for the differentiation of adipose tissue in vivo and in vitro.
A dual PPAR agonist, Lipaglyn(TM) has a predominant affinity to PPAR alpha and moderate affinity to PPAR gamma
Growth arrest (40%) and PPAR gamma
mRNA and protein upregulation was achieved with gamma-tocopherol within 6 h.
Activation of PPAR gamma
may mediate a portion of the anticancer activity of conjugated linoleic acid.
The PAX8/ PPAR gamma
fusion oncogene as a potential therapeutic target in follicular thyroid carcinoma.
For the study, the researchers introduced MCPIP to living cells from mice that had been stripped of the PPAR gamma
gene and found that the cells still completed the developmental process necessary to build fat.
By activating PPAR gamma
in adipocytes, Paractin may help maintain healthy blood sugar levels.
with overexpresssion of HER2/neu or overexpression of epidermal growth factor receptor, are treated with strongly binding PPAR gamma
ligands, and patients affected with cancer associated with overexpression of at least one member of the class I family of receptor tyrosine kinases selected from the group consisting of HER-2/neu and epidermal growth factor rector, comprising administering to said patient a therapeutically effective amount of a ligand of peroxisome proliferator-activated receptor gamma (PPAR gamma
) which has a pKi of at least 4.
Together, these manuscripts establish that MLR-1023 is a next generation insulin sensitizer that works independently of PPAR gamma
is required for placental, cardiac, and adipose tissue development.
With a predominant affinity to PPAR alpha isoform and moderate affinity to PPAR gamma
isoform of PPAR nuclear receptor subfamily, the molecule has shown beneficial effects on lipids and glycemic control without side effects.