POU2F3

POU2F3

A gene on chromosome 11q23.3 that encodes a transcription factor which binds to and regulates expression of various genes, such as SPRR2A or CSH1. POU2F3 is expressed in epidermis and keratinocytes.
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Using this 'CRISPR screen', the team found that a transcription factor called POU2F3 is expressed exclusively in the minority of SCLC tumours with low levels of neuroendocrine markers.