POMC


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Related to POMC: ACTH

POMC

Abbreviation for proopiomelanocortin.
Farlex Partner Medical Dictionary © Farlex 2012

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

POMC

Abbreviation for proopiomelanocortin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

POMC

Abbrev. for PROOPIOMELANOCORTIN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
In further tests, the investigators explored the signals that are "downstream" of POMC and AgRP cell activation, revealing that their influence extends widely in the brain, encompassing even regions in the cortex that control perception, memory, and attention.
Long-term effects of neonatal cigarette smoke exposure on POMC and MC4R in the hypothalamus.
Many AgRP/NPY- and POMC-producing neurons in the ARC coproduce the LepR and orexin 1 receptor (OX1R) (63), and orexin neurons can depolarize AgRP neurons (64) and POMC neurons (65).
Subcloned chimeric constructs which contained the rat Pomc genomic DNA and luciferase cDNA (pGL3-Basic, Promega, Madison, WI) were used for the studies of transient transfection: rPomc-Luc (-703/+58-Luc: harboring the rat Pomc 5,-flanking region from -703 to +58 relative to the transcription start site upstream of the luciferase cDNA in pGL3-Basic), -429/+58-Luc, -379/+58Luc, -359/+58-Luc, -293/+58-Luc, -169/+58-Luc, and +12/+58-Luc.
One of the most notable is the POMC gene that encodes a proopiomelanocortin, a precursor of anorexigenic neuro-peptides (ACTH) and [alpha]-melanocyte-stimulating hormone ([alpha]MSH).
Spengler, "Early-life stress reduces DNA methylation of the Pomc gene in male mice," Endocrinology, vol.
Rhythm recently initiated a Phase 3 clinical trial of setmelanotide in POMC deficiency obesity.
At the anterior pituitary, CRF binds to CRF1 receptors and stimulates specific cells (i.e., corticotropic cells) to synthesize and secrete a peptide called proopiomelanocortin (POMC).
In addition, we further found that central administration of visfatin led to anorexia and body weight loss, at least in part, via promoting the activity of proopiomelanocortin (POMC) neurons.
The ARC contains two major subpopulations of neurons for controlling appetite: orexigenic neurons that coexpress neuropeptide Y (NPY) and agouti-related protein (AgRP) and anorexigenic neurons that express peptide proopiomelanocortin (POMC) [22,23].
Alpha-melanocyte-stimulating hormone ([alpha]-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC) [1].