POLR2A | definition of POLR2A by Medical dictionary
Also found in: Acronyms
POLR2A A gene on chromosome 17p13.1 that encodes the largest subunit of DNA-dependent RNA polymerase II, the polymerase responsible for synthesising messenger RNA in eukaryotes. In combination with several other polymerase subunits, POLR2A forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Raw data were processed to normalized relative gene expression values with qBase plus software (Biogazelle, Zwijnaarde, Belgium) using IPO8, POLR2A
, UBC, and GAPDH as reference genes for data normalization (see Supplemental Material, Table S1).
Gene Gene name Microarray RT symbol FC PCR FC 1 TBP TATA box binding 2.37 1.29 protein 2 APOL1 Apolipoprotein 1.64 3.59 L 3 ICAM1 Intercellular 2.63 1.94 adhesion molecule 1 4 POLR2A
Polymerase (RNA) -1.99 0.69 II (DNA directed) polypeptide A 5 SLA Src-like-adaptor -1.85 0.43 6 HYAL1 Hyaluronoglucosaminidase -2.12 0.42 1 7 IRF5 Interferon -2.25 0.89 regulatory factor 5 8 IL2 Interleukin 2 -2.10 0.58 Table 2: (a) List of genes whose expression was downregulated at all the three time points.
Expression values were normalized to the housekeeping gene POLR2A
amplified in the same sample.