POLR2A


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POLR2A

A gene on chromosome 17p13.1 that encodes the largest subunit of DNA-dependent RNA polymerase II, the polymerase responsible for synthesising messenger RNA in eukaryotes. In combination with several other polymerase subunits, POLR2A forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
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Raw data were processed to normalized relative gene expression values with qBase plus software (Biogazelle, Zwijnaarde, Belgium) using IPO8, POLR2A, UBC, and GAPDH as reference genes for data normalization (see Supplemental Material, Table S1).
Gene Gene name Microarray RT symbol FC PCR FC 1 TBP TATA box binding 2.37 1.29 protein 2 APOL1 Apolipoprotein 1.64 3.59 L 3 ICAM1 Intercellular 2.63 1.94 adhesion molecule 1 4 POLR2A Polymerase (RNA) -1.99 0.69 II (DNA directed) polypeptide A 5 SLA Src-like-adaptor -1.85 0.43 6 HYAL1 Hyaluronoglucosaminidase -2.12 0.42 1 7 IRF5 Interferon -2.25 0.89 regulatory factor 5 8 IL2 Interleukin 2 -2.10 0.58 Table 2: (a) List of genes whose expression was downregulated at all the three time points.
Expression values were normalized to the housekeeping gene POLR2A amplified in the same sample.