POLD3

POLD3

A gene on chromosome 11q14 that encodes a member of the DNA polymerase delta complex involved in DNA replication and repair, which is required for optimal DNA polymerase delta activity.
References in periodicals archive ?
DNA repair array gene expression results showed that when this patient's results compare with the other NF1 patients without malignancy; ATR, CCNO, MLH1, NEIL1, NTHL1, RAD18, RAD 51, XRCC1, XRCC3 genes are overexpressed and ATM, BRCA1, BRCA2, ERCC4, EXO1, FEN1, LIG1, LIG3, MPG, MRE11A, MSH2, NEIL2, PMS1, POLD3, RFC1, SMUG1, TDG, TOP3B genes are down-regulated in this patient (mother).
Farrington et al., "Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk," Nature Genetics, vol.
The third affected a gene called POLD3 which influences two pathways that repair DNA damage.