POLD1

POLD1

A gene on chromosome 19q13.3 that encodes a member of the DNA polymerase delta complex involved in DNA replication and repair. POLD1 has two enzymatic activities: DNA synthesis (polymerase) and exonucleolytic activity, which degrades single-stranded DNA in the 3' to 5' direction.
References in periodicals archive ?
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Recently, whole-genome sequencing of constitutional DNA from individuals diagnosed with multiple colorectal adenomas by age 60 years revealed that a germline mutation (Ser478Asn) in the POLD1 [polymerase (DNA directed), delta 1, catalytic subunit] gene, which encodes the catalytic subunit of polymerase [delta] that promotes lagging-strand synthesis during DNA replication, is linked to an inherited predisposition to both colorectal cancer and endometrial cancer (12).