permanent neonatal diabetes mellitus

(redirected from PNDM)
Also found in: Acronyms.

permanent neonatal diabetes mellitus

An autosomal dominant condition (OMIM:176730) characterised by insulin-requiring hyperglycaemia diagnosed shortly after birth and the need for lifelong insulin therapy.

Molecular pathology
Caused by defects in INS that prevent normal folding and progression of proinsulin in the insulin secretory pathway.
References in periodicals archive ?
The patient was managed in between acute episodes with insulin for PNDM and pancreatic enzymes replacement therapy and daily oral prophylactic antibiotic.
She presented with PNDM and cyclic neutropenia at six-weeks of age.
The PNDM is a group affecting 40-50% cases with no remission.
2 and SUR1 subunits of the pancreatic ATP-sensitive potassium channel respectively have been implicated in the genesis of PNDM.
Based on this knowledge and fruitful sector dialogue, a flexible programmatic series of two development policy loans (DPLs) was developed and approved in 2009 to support the first phase of the PNDM and contribute to incentivize municipalities to modernize solid waste management services.