permanent neonatal diabetes mellitus

(redirected from PNDM)
Also found in: Acronyms.

permanent neonatal diabetes mellitus

An autosomal dominant condition (OMIM:176730) characterised by insulin-requiring hyperglycaemia diagnosed shortly after birth and the need for lifelong insulin therapy.

Molecular pathology
Caused by defects in INS that prevent normal folding and progression of proinsulin in the insulin secretory pathway.