BRCA1(redirected from PNCA4)
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BRCA1A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.
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BRCA1Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.