MCM7(redirected from PNAS146)
MCM7A gene on chromosome 7q21.3-q22.1 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. Cyclin D1-dependent kinase (CDK4) associates with MCM7 and may regulate its binding to RB1/RB, the tumour suppressor protein. MCM7 interacts with ATR-ATRIP complex, MCMBP, RAD17 and TIPIN.
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