SCN8A

(redirected from PN4)

SCN8A

A gene on chromosome 12q13 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN8A protein product is required for rapid membrane depolarisation, resulting in action potentials in excitable neurones.

Molecular pathology
SCN8A mutations are associated with mental retardation, pancerebellar atrophy and ataxia.
References in periodicals archive ?
The Condor NVP2000xX has three DisplayPort++ video outputs available from the rear XMC I/O connector Pn6 while the Condor NVP2000xPF has one Dual-Link and one Single-Link DVI video output available from the rear PMC I/O connector Pn4. The front panel supports one Dual-Link DVI and one DisplayPort++ video output.
Moreover, companies that are listed under distressed companies (PN4 Companies) are also excluded from the sample.
Il est constitue, lorsqu'il est complet, de cinq elements qui sont: la situation initiale (PN1) (1), la presence d'un nLud (PN2), les peripeties (PN3), le denouement (PN4), et la situation finale (PN5).
If the entire indicators are compared, pN1 have 11 score reduction, and pN2-pN3 have 9 score reduction (-), while pN4 have 7 score reduction especially in the "centrality" measurement.
The wine was inoculated with selected wine LAB Enoferm Alpha, Enoferm Beta or PN4; nutrient supplements were added at the 20 g/hL level.
(PN4) [v.sub.p] [less than or equal to] [[tau].sup.*]([v.sub.ap], [v.sub.(1- a)p]) for all a in [0,1].
In a separate announcement, pursuant to Section 5 of PN4, on 2 July 2001, the Company submitted an application to the Kuala Lumpur Stock Exchange (KLSE) for an extension of time to obtain all the approvals necessary to implement its plan to regularize its financial condition.
Todorov analisou contos literarios e a partir dessa analise ele pressupoe que uma estrutura narrativa deve conter cinco elementos obrigatoriamente: (a) a situacao de equilibrio do inicio (Pn1); (b) a degradacao dessa situacao pelo surgimento de algo que a problematiza (Pn2); (c) o estado de desequilibrio resultante desse problema (Pn3); (d) a busca em restabelecer o estado de equilibrio anterior (Pn4); (e) o restabelecimento do equilibrio inicial (Pn5).
(a) TTX [alpha] subunit Older names sensitivity [Na.sub.v] 1.1 Rat I, HBSCI, GPBI, TTX-S SCN1A [Na.sub.v] 1.2 Rat II, HBSCII, HBA TTX-S [Na.sub.v] 1.3 Rat III TTX-S [Na.sub.v] 1.4 SkM1, [micro]1 TTX-S [Na.sub.v] 1.5 SkM2, H1 TTX-R [Na.sub.v] 1.6 NaCh6, PN4, Scn8a, TTX-S Cerlll [Na.sub.v] 1.7 NaS, hNE-NA, PN1 TTX-S [Na.sub.v] 1.8 SNS, PN3, NaNG TTX-R [Na.sub.v] 1.9 NaN, SNS2, PN5, TTX-R NaT, SCN12A [Na.sub.x] [Na.sub.v] 2.1, [Na.sub.v] 2.3 Na-G, ?