SCN9A

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SCN9A

A gene on chromosome 2q24 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN9A protein product plays a major role in nociception signalling.

Molecular pathology
SCN9A mutations are associated with primary erythromelalgia, channelopathy-associated insensitivity to pain and paroxysmal extreme pain disorder.
References in periodicals archive ?
22) (=(10)) Request, PN1 (Be conventionally indirect) Bass.
Levels of neurotransmitters from groups of dams sacrificed at offspring PN1 and day 21 were measured in frontal cortex, nucleus accumbens, and striatum.
Changes in PN1 nucleus accumbens neurotransmitter levels were exclusively restricted to the S/150 group, with marginal increases in levels of DOPAC [64%; interaction of Pb and stress: F(1,26) = 3.
The only change seen in striatum at PN1 was, as in nucleus accumbens, confined to the S/150 group, where increases in DOPAC levels of 57% were noted [main effect of Pb: F(1,30) = 5.
NetBlazer PN1 $2,499 $2,049 NetBlazer PN1 Hub 3,049 2,149 NetBlazer PN2 2,299 1,849 NetBlazer PN2 Hub 2,699 1,949 NetBlazer PN4 2,699 1,949 NetBlazer PN4 Hub 3,099 2,049
Tenders are invited for Supply of Pneumatic timers time delay relay-electro pneumatic type: PN1, time (0-30 secs) with time block 1NO plus 1NC, instantaneous block 1NO plus 1NC having coil voltage: 110V, A.
Effective immediately, the North American suggested list prices will decrease between $200 and $600 on the following Telebit routers: NetBlazer PN1, NetBlazer PN1 Hub, NetBlazer PN2 Hub, NetBlazer PN4 and NetBlazer PN4 Hub.
Product New Price Previous Price NetBlazer PN1 $2,499 $2,699 NetBlazer PN1 Hub $3,049 $3,399 NetBlazer PN2 Hub $2,699 $2,999 NetBlazer PN4 $2,699 $2,999 NetBlazer PN4 Hub $3,099 $3,699