PLCG1

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PLCG1

A gene on chromosome 20q12-q13.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays an important role in regulating signalling cascades. PLCG1 is activated by ligand-mediated activation of receptor-type tyrosine kinases (e.g., PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4) and plays a role in actin reorganisation and cell migration.
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PLC1 participates in the intracellular transduction of receptor-mediated tyrosine kinase activators and may participate in the inflammation reaction through a specific function [52, 53].
Phospholipase C1 (PLC1) is a signaling protein that promotes protein kinase C and enhancing calcium signaling.
Professor Marco Falasca, who led the research team, said: "Consistent with these data we detected an increase in PLC1 expression in metastases compared to primary tumours in breast cancer patients.
The following trusts are available for investment through SAVEit: Gartmore Asia Pacific Trust PLC; Gartmore European Investment Trust plc; Gartmore Fledgling Trust plc1; Gartmore Global Trust PLC; Gartmore Growth Opportunities plc2; Gartmore Irish Growth Fund PLC3; Gartmore Smaller Companies Trust plc.
Total solids loss on the bare soil was significantly higher than all but one of the compost treatments (PLC1).