PLCG1

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PLCG1

A gene on chromosome 20q12-q13.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays an important role in regulating signalling cascades. PLCG1 is activated by ligand-mediated activation of receptor-type tyrosine kinases (e.g., PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4) and plays a role in actin reorganisation and cell migration.
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Lack of PLC1 interferes with normal development and is associated with reduced nephrin and podocin expression.
Professor Marco Falasca, who led the research team, said: "Consistent with these data we detected an increase in PLC1 expression in metastases compared to primary tumours in breast cancer patients.
Treatment name Description/Primary feedstocks Replicates PLC1 Poultry Gold Compost/Composted poultry litter 2 PLC2 Sargents Nutrients Compost/Composted poultry litter 2 PL Aged Poultry Litter/Layer manure from underhouse storage 2 MSC Cobb County Compost/Municipal solid waste compost, biosolids 2 BSC Erthfood Compost/Biosolids, peanut hulls 3 FWC Creative Earth Compost/Food residuals, ground wood waste 2 YWC UGA Compost/Yard waste, ground wood waste, some manure 3 WMf Woodtech Superfine Mulch/Finely ground wood mulch 2 WMm Woodtech Medium Hardwood Mulch/Medium ground wood mulch 3 WM2 Rockdale County Mulch/Coarse ground yard waste and waste wood 2 Soil Bare soil control 3 Table 2.