phosphatase

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phosphatase

 [fos´fah-tās]
any of a group of enzymes capable of catalyzing the hydrolysis of esterified phosphoric acid, with liberation of inorganic phosphate, found in practically all tissues, body fluids, and cells, including erythrocytes and leukocytes.
acid phosphatase see acid phosphatase.
alkaline phosphatase see alkaline phosphatase.

phos·pha·tase

(fos'fă-tās),
Any of a group of enzymes (EC 3.1.3.x) that liberate orthophosphate from phosphoric esters.
See also: phosphohydrolases.

phosphatase

(fŏs′fə-tās′, -tāz′)
n.
Any of numerous enzymes that catalyze the removal of phosphate groups by hydrolysis of phosphate ester bonds. They act in the opposite manner to kinases and are important in metabolism and cell signaling.

phos·pha·tase

(fos'fă-tās)
Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.

phosphatase

An enzyme that removes phosphate groups from a molecule.

phosphatase

an enzyme that catalyses the release of phosphate from a molecule. For example, in the mammalian liver phosphorylated glucose can be broken down to glucose with a phosphatase enzyme. see GLYCOGEN.

phos·pha·tase

(fos'fă-tās)
Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.
References in periodicals archive ?
This is the main idea of PLAP. Teachers are required to assist each individual child in the class to mentally reach the level appropriate to the grade s/he is physically in without having to physically move back a few grades.
Each case was stained with PLAP, CD-117, OCT-4, CK, CD-30 and AFP markers, which are routinely used in the diagnosis of germ cell tumours.
The trophoblastic markers hPL, PLAP, and keratin CK(AE1/AE3) were used for this purpose.
Immunohistochemistry is helpful in the diagnosis and markers of benefit include placental alkaline phosphatase (PLAP) and alpha-fetoprotein (AFP) although they are lacking in sensitivity and specificity.
The immune reactivity of germ cell tumors for PLAP was as follows: 98% of cases with seminomatous elements were PLAP positive.
Total 52 immunostains were included in the study and following primary antibodies were used- CK7, CK20, CA125, WT1, CEA, ER, PR, PLAP, AFP, CD30, S100.
PET and PLAP in suspected testicular cancer relapse: beware sarcoidosis.
(212,232,252,256) We recommend an initial panel consisting of sal-like 4 (SALL4), placental-like alkaline phosphatase (PLAP), inhibin [alpha], and calretinin to differentiate between GCTs and SCSTs; if all 4 markers show negativity, then other neoplasms such as adenocarcinomas, melanoma, or lymphoma should be considered.
Tumour tissue stained positive for CK7/20 and CDX2 but negative for PSA/Placental alkaline phosphatase (PLAP).
We also propose integration of these markers with other specific markers, such as [alpha]-fetoprotein (AFP), and with characteristic but nonspecific ones such as cytokeratins, CD30, podoplanin (D2-40), placental alkaline phosphatase (PLAP), c-KIT (CD117), and glypican-3 (GLP3).
(39) Immunophenotypically, sex cord-stromal tumors are often positive for inhibin, Melan-A, and calretinin and are uniformly negative for fetal germ cell and other markers that stain seminoma, including OCT3/4, SALL4, PLAP, CD117, and D2-40.
The germ cell tumors are typically positive for placental alkaline phosphatase (PLAP), octamerbinding transcription factor 4 (OCT4), and CD30 (positive in embryonal carcinoma), whereas malignant mesotheli omas of the tunica vaginalis testis are negative for these markers.