PLAG1

PLAG1

A gene on chromosome 8q12 that encodes PLAG1, a zinc finger transcription factor that is consistently rearranged in pleomorphic adenomas of the salivary gland. PLAG1 activation results in upregulation of IGFII, leading to uncontrolled cell proliferation in cultured cells; other genes upregulated by PLAG1 include CRLF1, CRABP2, CRIP2 and PIGF.

Molecular pathology
PLAG1 overexpression occurs in pleomorphic adenomas of the salivary gland, lipoblastoma and hepatoblastoma, and co-operates with CBFB-MYH11, a fusion gene in myeloid leukaemia.
References in periodicals archive ?
PLAG1 has been found to be associated with cattle height [20].
Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.
The most commonly detected recurrent chromosomal rearrangement detected in PA is the t(3;8)(p21;q12), resulting in increased PLAG1 gene expression because its transcriptional regulation is placed under the control of the constitutively active [beta]-catenin CTNNB1 gene promoter.
Rearrangements involving PLAG1 in PA cause an overexpression of the protein, which can be detected with PLAG1 IHC.
Although PLAG1 rearrangements in pleomorphic adenomas (PAs) have been known for some time now, it has other SGTs, especially carcinomas have been found to have translocations as well.
The target gene in PAs with 8q12 abnormalities is PLAG1, and the translocations lead to activation of PLAG1 expression.
PLAG1 encodes a DNA-binding zinc finger protein, controls PLAG1 target genes and insulin-like growth factor 2 signaling pathways.
Microarray screening for target genes of the proto-oncogene PLAG1.
75) A proportion of myoepithelial tumors of the skin and soft tissue with tubuloductal differentiation show recurrent PLAG1 rearrangements similar to those in mixed tumors of the salivary glands (pleomorphic adenomas), (87,88) which have not been described in AFH.
Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation.
An alternative approach would be to use a panel of immunomarkers including MYB, PLAG1, and CD117.
Pleomorphic adenoma gene 1 (PLAG1) is a protooncogene that is activated by recurrent chromosome rearrangements in pleomorphic adenoma, resulting in PLAG1 protein overexpression.