PLAG1

PLAG1

A gene on chromosome 8q12 that encodes PLAG1, a zinc finger transcription factor that is consistently rearranged in pleomorphic adenomas of the salivary gland. PLAG1 activation results in upregulation of IGFII, leading to uncontrolled cell proliferation in cultured cells; other genes upregulated by PLAG1 include CRLF1, CRABP2, CRIP2 and PIGF.

Molecular pathology
PLAG1 overexpression occurs in pleomorphic adenomas of the salivary gland, lipoblastoma and hepatoblastoma, and co-operates with CBFB-MYH11, a fusion gene in myeloid leukaemia.
References in periodicals archive ?
PLAG1 gene alterations in salivary gland PA and carcinoma ex PA: a combined study using chromosomal banding, in situ hibridisation and immunocytochemistry.
In fact, a specific translocation t(3;8)(p21;q12) involving PLAG1 and CTNNB1 (the gene encoding [beta]-catenin) can be found in 50% to 60% of pleomorphic adenomas.
In addition, [9] identified QTL for carcass weight on BTA 14 harboring pleomorphic adenoma gene 1 (PLAG1) gene in Japanese Black cattle.
Three tumors carried rearrangements of the long arm of chromosome 12 (the target gene of this 12q aberration was HMGA2), three others had 8q rearrangements (the target gene of the 8q aberration was PLAG1), one tumor had deletion of the long arm of chromosome 7, del(7) (q22), and one had aberrations of chromosome bands 3q21~23 and 11q21~22 [27].
PLAG1 (8q12.1) and HMGA2 (12q14.3) rearrangements are the most common genetic events in pleomorphic adenomas [18].
ID miRNA Sequence MIMAT0000104 hsa-miR-107 50-agcagcauuguacagggcuauca-72 MIMAT0000765 hsa-miR-335-5p 16-ucaagagcaauaacgaaaaaugu-38 MIMAT0000083 hsa-miR-26b-5p 12-uucaaguaauucaggauaggu-32 ID Target MIMAT0000104 PLAG1, BACE1, CDK6, GRN, DAPK 1, PTEN, NOTCH 2, NFIA, SERBP1 MIMAT0000765 TNC, RASA1, IGFR1, SP1, APBB2 MIMAT0000083 SLC17A6, (DNP1/vGLUT2) Note.
Xu et al., "miR-141 contributes to fetal growth restriction by regulating PLAG1 expression," PLoS ONE, vol.
Although PLAG1 rearrangements in pleomorphic adenomas (PAs) have been known for some time now, it has other SGTs, especially carcinomas have been found to have translocations as well.
The QTL effect on both BW and CBC may be due to the candidate gene pleiomorphic adenoma gene 1 (PLAG1) and/or neuropeptides B/W receptor 1 (GPR7).
One of the first chromosomal rearrangements described in salivary gland tumors was described (1,2) in PA nearly 2 decades ago: PA commonly shows rearrangements involving 8q12, resulting in increased pleomorphic adenoma gene 1 (PLAG1 zinc finger) gene expression.
The translocations/rearrangements result in gene fusions involving the transcription factor-encoding genes pleomorphic adenoma gene 1(PLAG1) and high-mobility group AT-hook 2 (HMGA2).
(75) A proportion of myoepithelial tumors of the skin and soft tissue with tubuloductal differentiation show recurrent PLAG1 rearrangements similar to those in mixed tumors of the salivary glands (pleomorphic adenomas), (87,88) which have not been described in AFH.