PLA2R1

PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.
References in periodicals archive ?
Beyond the lipoquality control by s[PLA.sub.2]s, several s[PLA.sub.2]s binds to s[PLA.sub.2] receptor (PLA2R1, also known as the C-type lectin Clec13c) with different affinities.
Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.
HLA-DQA1 and PLA2R1 polymorphisms and risk of idiopathic membranous nephropathy.
My group has recently identified 2 causative antigens (neutral endopeptidase and bovine serum albumin) in children, and 2 predisposing genes HLA-DQA1 and PLA2R1 coding for another antigen in adult MN.
In a joint analysis, comprising 556 patients with primary MN and 2338 controls, the authors identified the most significant association within HLA-DQA1 and PLA2R1 on chromosome 2q24 [62].
A study from India compared 114 cases and 95 healthy controls and observed differences in the PLA2R1 and HLA-DQA1 SNPs which became more evident when studying PLA2R-related cases only [22].
Analysis of 1112 Chinese patients and 1020 healthy controls revealed a strong association between three SNPs within PLA2R1 and one SNP within HLA-DQA1 and a potentiation when risk alleles were combined [67].
In general, the presence of HLA-DQA1 and PLA2R1 risk alleles confers a significant association with primary MN and the combination of risk phenotypes potentiates the risk to develop MN in most ethnicities.
In contrast to PLA2R1, THSD7A is expressed on both murine and human podocytes, and administration of human anti-THSD7A antibodies bind to murine THSD7A, leading to proteinuria and a histopathology resembling MN [77].
El PLA2R1 (del ingles Phospholipase A2 receptor 1) es una proteina de 180KD, transmembranal del tipo I, cuyo gen codificante se encuentra en el cromosoma 2(2q23-q24).
PLA2R1 tiene funciones accesorias, conclusiones tomadas a partir de que una version soluble de este receptor se deriva a partir del clivamiento (corte proteolitico) desde la membrana celular, accion catalizada por metalo-proteinasas, y otras versiones se derivan a partir del corte y empalme alternativo del ARNm.
Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles.