PLA2R1

PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.
References in periodicals archive ?
Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.
HLA-DQA1 and PLA2R1 polymorphisms and risk of idiopathic membranous nephropathy.
My group has recently identified 2 causative antigens (neutral endopeptidase and bovine serum albumin) in children, and 2 predisposing genes HLA-DQA1 and PLA2R1 coding for another antigen in adult MN.
El PLA2R1 (del ingles Phospholipase A2 receptor 1) es una proteina de 180KD, transmembranal del tipo I, cuyo gen codificante se encuentra en el cromosoma 2(2q23-q24).
PLA2R1 tiene funciones accesorias, conclusiones tomadas a partir de que una version soluble de este receptor se deriva a partir del clivamiento (corte proteolitico) desde la membrana celular, accion catalizada por metalo-proteinasas, y otras versiones se derivan a partir del corte y empalme alternativo del ARNm.
sup][6],[7],[8] Especially, a genome-wide association study (GWAS) for Caucasians identified HLA-DQA1 and PLA2R1 as the two most closely associated signals with IMN.