PLA2R1

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PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.
References in periodicals archive ?
Two hundred and thirty-one paraffin-embedded renal tissue sections from patients with histology diagnosis of iMN were tested for PLA2R [Figure 1].
Baseline clinical data at kidney biopsy were available for 186 of these 231 patients, including 145 renal PLA2R positive patients and 41 negative patients as summarized in [Table 1].
30 May 2014 - US FDA said yesterday it had authorised Euroimmun US Inc's Anti- PLA2R IFA blood test to help identify if membranous glomerulonephritis (MGN), a specific type of kidney disease, is due to the body's rejection of its own kidney tissue or due to another cause.