PRKAR1A

(redirected from PKR1)

PRKAR1A

A gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.

Molecular pathology
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a  thyroid tumour-specific chimeric oncogene.
References in periodicals archive ?
Ravi, Bolan, Cargo van, Cultus, Swift DLX and Swift DX now cost PKR647,000, PKR700,000, PKR676,000, PKR1.
Burgeoning electricity subsidies coupled with below target tax collection (Tax Collection 10MFY13 PKR1, 508 bn vs.
This sub-cluster also had six accessions KOS4 (US), KOS2 (Red-lady), CHP1 (Honey dew), CHP2 (Solo), PKR1 (Kiru) and EMB1 (Sunrise) identified with specific varietal names.
The bank said that its total assets increased to PKR1.
Unilever Pakistan, one of the country's largest food and drink companies, recently reported profits after tax of PKR1.
Ratings of the subordinated and unsecured TFCs issues of PKR1.
This criticism was backed-up by the Pakistan Medical Association (PMA), which pointed out the popular painkiller Ponstan (mefenamic acid) was being sold by a foreign drugmaker for PKR1 (US$0.
DEG-Deutsche Investitions had bought shares in Atlas Bank for PKR1.