PRKAR1A

(redirected from PKR1)

PRKAR1A

A gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.

Molecular pathology
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a  thyroid tumour-specific chimeric oncogene.
References in periodicals archive ?
FBR collects over PKR2trn in seven months | (BR): The Federal Board of Revenue (FBR) has recorded provisional net revenue collection of over PKR2trn during first seven months of the current financial year against PKR1,69bn collected during the same period of the previous fiscal year, recording an increase of more than PKR300bn.
He also announced a PKR1 crore reward for whoever identified the culprit behind the heinous crime.
Pakistan's FINCA Microfinance Bank has said that it has registered a PKR1.
ICI Pakistan Ltd (KAR: ICI) has signed asset purchase agreements with Wyeth Pakistan Ltd and Pfizer Pakistan Ltd detailing the acquisition of certain assets at the combined price of PKR1.
An enquiry conducted by the CCP's Cartel and Trade Abuses department found that JCR-VIS was dominant in the market for credit rating services in Pakistan and the submission of a token bid of PKR1 100 was insufficient to cover JCR's costs.
Coordinating Minister for Maritime Affairs, Rizal Ramli said: The Launching of PKR1 is a great momentum for the development of the Indonesian Shipbuilding and Maritime Industry.
Ravi, Bolan, Cargo van, Cultus, Swift DLX and Swift DX now cost PKR647,000, PKR700,000, PKR676,000, PKR1.
Burgeoning electricity subsidies coupled with below target tax collection (Tax Collection 10MFY13 PKR1, 508 bn vs.
This sub-cluster also had six accessions KOS4 (US), KOS2 (Red-lady), CHP1 (Honey dew), CHP2 (Solo), PKR1 (Kiru) and EMB1 (Sunrise) identified with specific varietal names.
The agency upheld also the A+ rating on the bank's PKR1.
According to Pakistan's central bank, The State Bank of Pakistan (SBP), Islamic banking industry deposits increased by PKR156bn, 10 percent quarter-on-quarter, to PKR1.