PKP2

PKP2

A gene on chromosome 12p11 that encodes plakophilin 2, which is thought to play a role in junctional plaques and contribute to epidermal morphogenesis.

Molecular pathology
Defects in PKP2 cause arrhythmogenic right ventricular dysplasia type 9.
References in periodicals archive ?
However truncating variants in these genes are likely to be actionable, especially in PKP2 where they occur in approximately 25% of ARVC patients (12).
5% muscle 1 DCM TTN Titin 13%-27% MYH7 Myosin, heavy chain 7 [congruent to] 5% LMNA Lamin A/C [congruent to] 5% DSP Desmoplakin [congruent to] 5% TNNT2 Troponin T2, cardiac type 2%-3% TPM1 Tropomyosin 1 (alpha) [congruent to] 2% TNNI3 Troponin I3, cardiac type <1% BAG3 BCL2 associated athanogene 3 N/A (a) RBM20 RNA binding motif protein 20 N/A ARVC PKP2 Plakophilin 2 25%-30% DSP Desmoplakin 9% DSG2 Desmoglein 2 3.
Mutations in PKP2 encoding plakophilin-2 are the most frequent.
In the other two studies, iPSC-derived cardiomyocytes of patients carrying two different mutations in PKP2 were generated.
PKP2 is a fun film about relationships from a male's perspective," said Ranjan.
Problem # 2 - construction of the power cable connection PKP2 Prabuty PT PT 3xXRUHAKXS Drought type cable 1x240 / 50 mm2 with a length of about 11 thousand.
The object of this contract was to develop in Polish project documentation, project construction and executive with obtaining the necessary permits, consents, agreements and duties of the author~s supervision duty in connection with the reconstruction of MV 15 kV PKP1 and PKP2 power PT Buda Zosiny accordance with the requirements of the customer.
2 - Construction of the power cable connection PKP2 Prabuty PT PT Drought type cable 3xXRUHAKXS 1x240 / 50 mm2 of about 11 thousand.
The object of this proceeding is to develop in Polish project documentation, project building and performing with obtaining the necessary permits, consents, agreements and duties of obligation to the author~s supervision in connection with the reconstruction of the line MV 15kV PKP1 and PKP2 power PT Buda Zosiny in accordance with the requirements of the Employer.
The contract is for the supply of new materials for the upgrading of 15 kV medium voltage power PKP1 and PKP2 PT Coaches.