RIPK4

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RIPK4

A gene on chromosome 21q22.3 that encodes a serine/threonine/ tyrosine kinase, which is a transcriptional target of TP63. RIPK4 plays a role in NF-kappaB activation, and it interacts with PRKCB, TRAF1, TRAF2, TRAF3, TRAF5, BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.

Molecular pathology
RIPK4 mutations cause popliteal pterygium syndrome, lethal type.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The conflict between Turkey and the PKK, which demands the creation of an independent Kurdish state, has lasted more than 25 years, claiming more than 40,000 lives.
Earlier on Saturday, the Turkish fighter jets pounded the hideouts and arms depots of the PKK in Kharkouk region.
Erdogan said the PKK losses were at least 10 times as high.
This step is the beginning of a terrorism investigation because it is most likely to unearth youths who have joined the PKK. Once they decide to return to Turkey, or when the PKK has decided to send them to Turkish cities, they need to find new ID cards to escape security radar.
Despite the tightened border, Kurds from Turkey remain well represented in the YPG, further underscoring the group's links to the PKK. In an interview with the Wall Street Journal, Kurdish fighter Zind Ruken expanded on the PKK-YPG relationship.
Jailed PKK leader (http://www.ibtimes.co.uk/articles/448781/20130321/pkk-ocalan-kurdish-ceasefire-turkey-truce.htm) Abdullah Ocalan announced the historical deal to end the 30-year conflict which has claimed more than 40,000 lives.
The intellectuals were and are considered still as an unreliable group, only and occasionally used for the purposes of the organization in some kind of ad hoc formations to bestow legitimacy upon the policies of the PKK. In accordance with its Marxist-Leninist ideology, to cite Lenin himself, the intelligentsia for PKK "is not "the brain of the nation", it is the" feces of the nation." PKK has changed its strategy, tactics and even ideology several times, not to mention the many names and labels it has coined: PKK, KADEK, Kongra-Gel.
Turkey has warned its citizens against travelling by land in Syria after reports that the Kurdistan Workers' Party (PKK) has resumed armed activity within Syria.
But even the most stalwart PKK militants and civilian supporters began to lose trust.
Turkey has been fighting the PKK since 1984, when it took up arms to carve out a homeland in southeastern Turkey.
Al-Maliki vowed to step up their co-operation against the PKK fighters whose presence has cast a shadow over Turkish-Iraqi relations.