PKD


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kidney disease, polycystic

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PKD

An inherited renal disorder transmitted as an autosomal recessive trait in infants and as an autosomal dominant trait in adults. PKD was previously termed adult polycystic kidney disease. It is characterized by cyst formation in ductal organs, particularly the kidney and liver, and by gastrointestinal and cardiovascular abnormalities. Included are colonic diverticula, cardiac valvular abnormalities, and intracranial and aortic aneurysms. Symptoms include hypertension, acute and chronic pain, and urinary tract infections. It is one of the most common hereditary disorders, occurring in about 1 in 400 to 1 in 1000 people. An estimated 500,000 persons have the disease in the U.S. It accounts for 10% of cases of end-stage renal disease. Treatment includes medical therapy for renal failure with eventual renal dialysis and renal transplantation.

polycystic kidney disease

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PKD

Any of several hereditary disorders in which cysts form in the kidneys and other organs, eventually destroying kidney tissue and function. The autosomal recessive form usually appears in early childhood; the autosomal dominant form usually develops later in life. Definitive treatments are dialysis and kidney transplant. Because cerebral aneurysms are commonly found in adults with PKD, patients with this disorder are often screened with computed tomography or magnetic resonance imaging studies of the brain.
References in periodicals archive ?
She highlighted that Montenegro is working on upgrading to third-generation e-passports and joining the ICAO PKD will be the pre-requisite to meeting the ICAO standards.
One hundred and sixty-five patients with PKD, including 138 males and 27 females, were recruited.
When they added back a healthy form of polycystin-1 to our patient cells, it traveled to the cilium and brought its partner polycystin-2 with it, suggesting a possible therapeutic approach for PKD. This was the first time induced pluripotent stem cells have been used to study human kidney disease where a defect related to disease mechanisms has been found.
"I have always been a runner and somebody who was running in aid of PKD dropped out, which meant they were looking for somebody to fill the place.
Gertrude Robert and her late husband, George, already had their children when he was diagnosed with PKD at age 40.
Meanwhile, several other drugs, including rapamycin, octreotide, and tolvaptan, that succeeded in animal tests for PKD are now being tested in people.
"We hope to meet with AVI very soon to discuss plans for further development of this drug in PKD patients."
PKD can cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain.
PKD is the most common of all life-threatening genetic diseases in the United States.
When PKD causes kidneys to fail--which usually happens only after many years--the patient requires dialysis or kidney transplantation.
The workshop brought together the heads of the Travel Document Issuing Authorities, chiefs of the IT Departments of the Travel Document Issuing Authorities and heads of the Passport Verification Departments from Albania, Bosnia and Herzegovina, Croatia, the former Yugoslav Republic of Macedonia and Montenegro, to get acquainted with the ICAO PKD, which enables countries to effectively validate the chip stored in electronic passports.
Palladio is developing its lead drug, lixivaptan, for PKD, an orphan kidney disease for which there are no drug treatments approved in the United States.