PKD


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PKD

abbreviation for polycystic kidney disease.

kidney disease, polycystic

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PKD

An inherited renal disorder transmitted as an autosomal recessive trait in infants and as an autosomal dominant trait in adults. PKD was previously termed adult polycystic kidney disease. It is characterized by cyst formation in ductal organs, particularly the kidney and liver, and by gastrointestinal and cardiovascular abnormalities. Included are colonic diverticula, cardiac valvular abnormalities, and intracranial and aortic aneurysms. Symptoms include hypertension, acute and chronic pain, and urinary tract infections. It is one of the most common hereditary disorders, occurring in about 1 in 400 to 1 in 1000 people. An estimated 500,000 persons have the disease in the U.S. It accounts for 10% of cases of end-stage renal disease. Treatment includes medical therapy for renal failure with eventual renal dialysis and renal transplantation.

polycystic kidney disease

,

PKD

Any of several hereditary disorders in which cysts form in the kidneys and other organs, eventually destroying kidney tissue and function. The autosomal recessive form usually appears in early childhood; the autosomal dominant form usually develops later in life. Definitive treatments are dialysis and kidney transplant. Because cerebral aneurysms are commonly found in adults with PKD, patients with this disorder are often screened with computed tomography or magnetic resonance imaging studies of the brain.
References in periodicals archive ?
4%) patients initially obtained the knowledge of PKD from network, 42 (25.
Palladio expects to leverage this data package and the learnings from recent PKD drug development activities to advance lixivaptan for PKD.
Gertrude Robert and her late husband, George, already had their children when he was diagnosed with PKD at age 40.
These drugs act at different points along a chain of abnormalities that we believe occurs in PKD,' he says.
Autosomal dominant PKD is the most common inherited form.
In June of 1994 investigators found the gene that causes 90 percent of PKD on chromosome 16.
These complications help doctors distinguish PKD from the usually harmless "simple" cysts that often form in the kidneys in later years of life.
The episodes of PKD usually start in childhood or early adolescence and tend to remit with age.
Premium offers include credit listing on the record for supporting the PKD Foundation, being a special VIP guest at next year's Berks Jazz Festival, and meeting the musicians on BOP.
While scientists had already identified flawed genes at the heart of most cases of PKD, a research group now suggests that odd microbes, known as nanobacteria, play an equally important role in the disease's progression.
Physicians agree that the most important attributes for a new therapy to treat PKD is an ability for the drug to delay onset of ESRD, to improve or maintain glomerular filtration rate and to be safe in the long-term.
com)-- Recently, research has shown that a drug called Tolvaptan can dramatically slow the development and progression of polycystic kidney disease (PKD) in animal models, and another drug (octreotide) can delay the development of both PKD and polycystic liver disease and may prove to be a potential treatment option for people with liver involvement.