PRKCA

(redirected from PKCA)
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PRKCA

A gene on chromosome 17q22-q23.2 that encodes a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, which up- or downregulates cell proliferation, apoptosis, differentiation, migration and adhesion; tumourigenesis; cardiac hypertrophy; angiogenesis; and platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signalling cascades involving MAPK1/3 and RAP1GA.
References in periodicals archive ?
Moreover, we previously reported in the rat kidney that aldosterone injection for 30 minutes increased the protein abundance of PKC[alpha] and enhanced the immunoreactivity staining of PKCa in the PCT with the translocation from the basolateral to luminal membranes [11].
Capurro et al., "Early nongenomic events in aldosterone action in renal collecting duct cells: PKCa activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response," Journal of American Society of Nephrology, vol.
Furthermore, GTPs could attenuate the increase in the expression levels of PKCa mRNA and protein caused by cerebral ischemia.
In conclusion, curcumin inhibited TPA-induced invasion by reducing MMP-9 activation mainly through the PKCa, MAPK and NF-[kappa]B/AP-1 pathways in MCF-7 cells.
This subunit can be phosphorylated by all three isoforms of PKC: conventional or classical (PKCa, PKC[beta]), novel (PKC[delta], PKCe), and atypical (PKC[zeta] [118].
Molkentin, "PKCa regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)," Journal of Cell Biology, vol.
Other studies demonstrate that, in a murine carcinogenic model, DMBA-induced carcinogenesis in PKCa knockout mice tumor formation is suppressed but not tumor growth and progression [52].
PKCa is increased in the lungs of patients with COPD and is thought to be important in the hypertrophy and proliferation of airway smooth muscle cells [46].
This study shows that C19, KLF10, KLF15, KIAA1949, and RXR[beta] proteins can strongly respond to TPA stimulation and activate LCN2 transcription; the MEK [right arrow] ERK, JNK, and P38 kinases, but not PKCa, are involved in LCN2 transactivation, indicating cell-specific regulation of LCN2.
Lu et al., "Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCa signalling pathway in human umbilical vein endothelial cells," British Journal of Pharmacology, vol.
Li et al., "Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCa and PI3K/AKT signaling pathways," Journal of Agricultural and Food Chemistry, vol.
Jeong, "Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCa during non-amyloidogenic processing," FEBS Letters, vol.