PRKCA

(redirected from PKCA)
Also found in: Acronyms.

PRKCA

A gene on chromosome 17q22-q23.2 that encodes a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, which up- or downregulates cell proliferation, apoptosis, differentiation, migration and adhesion; tumourigenesis; cardiac hypertrophy; angiogenesis; and platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signalling cascades involving MAPK1/3 and RAP1GA.

References in periodicals archive ?

Moreover, we previously reported in the rat kidney that aldosterone injection for 30 minutes increased the protein abundance of PKC[alpha] and enhanced the immunoreactivity staining of PKCa in the PCT with the translocation from the basolateral to luminal membranes [11].

Capurro et al., "Early nongenomic events in aldosterone action in renal collecting duct cells: PKCa activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response," Journal of American Society of Nephrology, vol.

Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney

Furthermore, GTPs could attenuate the increase in the expression levels of PKCa mRNA and protein caused by cerebral ischemia.

Green tea polyphenols alleviate early blood brain barrier damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signalling

In conclusion, curcumin inhibited TPA-induced invasion by reducing MMP-9 activation mainly through the PKCa, MAPK and NF-[kappa]B/AP-1 pathways in MCF-7 cells.

Curcumin suppresses the TPA-induced invasion through inhibition of PKC[alpha]-dependent MMP-expression in MCF-7 human breast cancer cells

This subunit can be phosphorylated by all three isoforms of PKC: conventional or classical (PKCa, PKC[beta]), novel (PKC[delta], PKCe), and atypical (PKC[zeta] [118].

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Molkentin, "PKCa regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)," Journal of Cell Biology, vol.

Signaling Pathways in Cardiac Myocyte Apoptosis

Other studies demonstrate that, in a murine carcinogenic model, DMBA-induced carcinogenesis in PKCa knockout mice tumor formation is suppressed but not tumor growth and progression [52].

From normal skin to squamous cell carcinoma: a quest for novel biomarkers

PKCa is increased in the lungs of patients with COPD and is thought to be important in the hypertrophy and proliferation of airway smooth muscle cells [46].

Inflammatory signalings involved in airway and pulmonary diseases

This study shows that C19, KLF10, KLF15, KIAA1949, and RXR[beta] proteins can strongly respond to TPA stimulation and activate LCN2 transcription; the MEK [right arrow] ERK, JNK, and P38 kinases, but not PKCa, are involved in LCN2 transactivation, indicating cell-specific regulation of LCN2.

Cell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma

Lu et al., "Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCa signalling pathway in human umbilical vein endothelial cells," British Journal of Pharmacology, vol.

Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-[kappa]B Signaling Cascade: Protective Effects of Apocynin

Li et al., "Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCa and PI3K/AKT signaling pathways," Journal of Agricultural and Food Chemistry, vol.

BQ123 Stimulates Skeletal Muscle Antioxidant Defense via Nrf2 Activation in LPS-Treated Rats

Jeong, "Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCa during non-amyloidogenic processing," FEBS Letters, vol.