Moreover, we previously reported in the rat kidney that aldosterone injection for 30 minutes increased the protein abundance of PKC[alpha] and enhanced the immunoreactivity staining of PKCa in the PCT with the translocation from the basolateral to luminal membranes .
Capurro et al., "Early nongenomic events in aldosterone action in renal collecting duct cells: PKCa activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response," Journal of American Society of Nephrology, vol.
Furthermore, GTPs could attenuate the increase in the expression levels of PKCa
mRNA and protein caused by cerebral ischemia.
In conclusion, curcumin inhibited TPA-induced invasion by reducing MMP-9 activation mainly through the PKCa
, MAPK and NF-[kappa]B/AP-1 pathways in MCF-7 cells.
This subunit can be phosphorylated by all three isoforms of PKC: conventional or classical (PKCa
, PKC[beta]), novel (PKC[delta], PKCe), and atypical (PKC[zeta] .
regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)," Journal of Cell Biology, vol.
Other studies demonstrate that, in a murine carcinogenic model, DMBA-induced carcinogenesis in PKCa
knockout mice tumor formation is suppressed but not tumor growth and progression .
is increased in the lungs of patients with COPD and is thought to be important in the hypertrophy and proliferation of airway smooth muscle cells .
This study shows that C19, KLF10, KLF15, KIAA1949, and RXR[beta] proteins can strongly respond to TPA stimulation and activate LCN2 transcription; the MEK [right arrow] ERK, JNK, and P38 kinases, but not PKCa
, are involved in LCN2 transactivation, indicating cell-specific regulation of LCN2.
Lu et al., "Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCa
signalling pathway in human umbilical vein endothelial cells," British Journal of Pharmacology, vol.
Li et al., "Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCa
and PI3K/AKT signaling pathways," Journal of Agricultural and Food Chemistry, vol.
Jeong, "Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCa
during non-amyloidogenic processing," FEBS Letters, vol.