AKT1

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AKT1

A gene on chromosome 14q32.32|14q32.32 that encodes protein kinase B (PKB), a serine-threonine protein kinase that is rapidly and specifically activated by platelet-derived growth factor through phosphatidylinositol 3-kinase. PKB plays a key role in regulating cell survival, insulin signalling, angiogenesis, tumour formation and growth factor-induced neuronal survival. Activated AKT1 phosphorylates and inactivates components of the apoptotic machinery.
References in periodicals archive ?
The operations that will be acquired from PKB Korporacija cover several different agricultural and food sector activities.
PKB from to build a dedicated to brewing the coffee and Jon Rochelle Silverstein, associate director of retail and leisure at Allied London, said: "PKB are the perfect addition to Spinningfields and No.1.
The relative expression of proteins involved in the insulin signaling pathway was examined by Western blot including IRS-1, PKB, and PI3Kp85 (Table 3, Figures 1(a)-1(c)).
PKB understands the unique challenges presented by aerospace and guidance applications.
Structurally, the Pieniny Klippen Belt (PKB) corresponds to one of the main discontinuity zones in the Earth's crust extending along the Inner-Outer Carpathian border (Birkenmajer, 1974, 1986).
Those tumors showed increased phosphorylation of PKB, linking the malignant phenotype associated with PTEN loss with hyperactivation of the PI3K pathway.
* PKB Engineering, which provides comprehensive engineering and consulting services to the public and private sectors, leased 2,401 s/f at One JJarmon Plaza.
In January, Kirana raised some concerns among investors when he unexpectedly joined the small Islamic PKB party, which has since raised eyebrows by picking as its presidential candidate an aging pop star and polygamist who won some notoriety by once advising fellow believers not to vote for a non-Muslim.
Department of Transportation (DOT) with the required 90-day notice of its intent to discontinue scheduled service between Cleveland and five communities no later than May 15, 2014, including Jamestown, New York (JHW); Bradford, Pennsylvania (BFD); DuBois, Pennsylvania (DUJ); Franklin, Pennsylvania (FKL); and Parkersburg, West Virginia (PKB).
The project will be implemented by a company that was recently formed within PKB (Belgrade Agricultural Combine) - ''Zelena energija'' (Green Energy).
ArQule chief medical officer, Brian Schwartz, said, 'AKT, also known as the serine/threonine kinase PKB, is believed to mediate a number of signal transduction processes and represents a potential therapeutic target for several cancers and other diseases.'